Description
TGF-ß is the prototype of a protein superfamily which, in humans, contains at least 35 members, including activins, inhibins, bone morphogenetic proteins, growth/differentiation factors, and Müllerian inhibiting substance. This monograph draws on the worlds leading laboratories to comprehensively cover all aspects of the biology of TGF-? and serve as a reference work for both specialists and researchers less familiar with the field.
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Contents
Preface
Foreword
M.B. Sporn
1. The Discovery of TGF-?: A Historical Perspective
H.L. Moses and A.B. Roberts
2. TGF-? and the TGF-? Family
R. Derynck and M. Miyazono
CELL BIOLOGY
3. TGF-?: A Multipotential Cytokine
S.H. Schilling, A.B. Hjelmeland, J.N. Rich, and X.-F. Wang
4. Activins and Inhibins
E. Wiater and W. Vale
5. The Bone Morphogenetic Proteins
T. Katagiri, T. Suda, and K. Miyazono
SIGNALING
6. Signaling Receptors of the TGF-? Family
J.L. Wrana, B. Ozdamar, C. Le Roy, and H. Benchabane
7. TGF-? Bioavailability: Latency, Targeting, and Activation
B. Dabovic and D.B. Rifkin
8. Agonists and Antagonists of the TGF-? Family Ligands
C. Chang
9. TGF-? Signaling from Receptors to Smads
C.-H. Heldin
10. Transcriptional Control via Smads
X. Lin, Y.-G. Chen, and X.-H. Feng
11. Growth Control by TGF-?: Mechanisms Controlling Cell Cycle Progression and Apoptosis
P.M. Siegel and J. Massagué
12. Regulation of TGF-? Family Signaling by Inhibitory Smads
K. Miyazono
13. Structural Basis for TGF-? Family Receptor Assembly and Signaling Specificity
K. Lin and S. Choe
14. Non-Smad TGF-? Signaling Pathways
Y.E. Zhang
15. Regulation of the Smad Pathway by Signaling Cross-Talk
K. Luo
DIFFERENTIATION, DEVELOPMENT, AND PHYSIOLOGY
16. TGF-? Family Signaling in Early Postimplantation Development of the Mouse
S. Miura, M. Whitman, and Y. Mishina
17. TGF-? Family Signaling in Drosophila
G. Pyrowolakis, B. Hartmann, and M. Affolter
18. TGF-? Signaling in the Nematode C. elegans
G.I. Patterson and R.W. Padgett
19. TGF-? Family Signaling in Xenopus and Zebrafish Embryos
M. Whitman
20. TGF-? Family Signaling in Stem Cell Renewal and Differentiation
T. Watabe and K. Miyazono
21. TGF-? Family Signaling in Mesenchymal Differentiation
R. Derynck, E. Piek, R.A. Schneider, L. Choy, and T. Alliston
22. TGF-? Family Signaling in Skeletal Development, Maintenance, and Disease
T. Alliston, E. Piek, and R. Derynck
23. TGF-? Family in Epithelial Development
N.M. Muñoz and W.M. Grady
24. The TGF-? Family in Endothelial Cell Differentiation and Cardiovascular Development and Function
M.-J. Goumans, R. Carvalho, C. Mummery, and P. ten Dijke
25. TGF-? as a Regulator of Myeloid and Lymphoid Development and Function
J.J. Letterio and F.W. Ruscetti
26. The TGF-? Family in Neural and Neuronal Differentiation and Development
J. Samanta, M.A. Bonaguidi, and J.A. Kessler
27. The TGF-? Family in the Reproductive Tract
S.A. Pangas and M.M. Matzuk
CANCER AND DISEASE
28. TGF-? Signaling Pathway and Tumor Suppression
W.M. Grady and S.D. Markowitz
29. TGF-? Signaling in EpithelialMesenchymal Transition and Invasion and Metastasis
R.J. Akhurst
30. TGF-? and the Tumor Microenvironment
B. Bierie and H.L. Moses
31. TGF-? and Fibrosis
E.P. Böttinger
32. Development of TGF-?-based Therapeutic Agents: Capitalizing on TGF-?s Mechanisms of Action and Signal Transduction Pathways
C.L. Arteaga and J.M. McPherson
33. BMP-based Therapeutics and the BMP Signaling Pathways
G. Bain, A.J. Celeste, and J.M. Wozney
Index