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Table of contents Preface, Thomas Dittmar, Kurt S. Zänker (Witten/ Herdecke University, Witten, Germany); 1 Introduction, Thomas Dittmar, Kurt S. Zänker (Witten/ Herdecke University, Witten, Germany); 2 Heterochronic control of AFF-1-mediated cell-to-cell fusion in C. Elegans, Lilach Friedlander-Shani, Benjamin Podbilewicz (Israel Institute of Technology, Haifa, Israel); 3 Role of SNAREs in membrane fusion, Bahnu P. Jena (Wayne State University School of Medicine, Detroit, MI, USA); 4 Molecular and cellular mechanisms of mammalian cell fusion, Xiaofeng Zhou, Jeffrey L. Platt (University of Michigan, Ann Arbor, MI, USA); 5 Membrane fusions during mammalian fertilization, B.M. Gadella (Utrecht University, Utrecht, The Netherlands), Janice P. Evans (John Hopkins University, Baltimore, MD, USA); 6 Trophoblast fusion, Berthold Huppertz, Martin Gauster (Medical University Graz, Graz, Austria); 7 Macrophage fusion and multinucleated giant cells of inflammation, Amy K. McNally, James M. Anderson (Case Western Reserve University, Cleveland, OH, USA); 8 Molecular mechanisms of myoblast fusion across species, Adriana Simionescu, Grace K. Pavlath (Emory University, Atlanta, GA, USA); 9 Cell-fusion-mediated reprogramming: Pluripotency of transdifferentiation? Implications for regenerative medicine, Daniela Sanges, Frederic Lluis, Maria Pia Cosma (Center for Genomic Regulation, Barcelona, Spain); 10 Cell fusion and tissue regeneration, Manuel Álvarez-Dolado, Magdalena Martínez-Losa (Andalusian Center for Molecular Biology and Regenerative Medicine, Seville, Spain); 11 Dendritic cell-tumour cell fusion vaccines, Walter T. Lee (Duke University Medical Center, Durjam, NC, USA); Index

 

Although cell fusion is an omnipresent process in life, to date considerably less is still known about the mechanisms and the molecules being involved in this biological phenomenon in higher organisms. In Cell Fusion in Health and Disease Volume 1 international leading experts will present up-to-date overviews about the current knowledge about cell fusion-mediating molecules in C. elegans and mammalian cells. Further topics of the book will focus on cell fusion in physiological processes including fertilization, placentation, skeletal muscle development, and tissue repair and will sum up the use of artificial cell fusion for cellular reprogramming and cancer vaccine development. Thus, Cell Fusion in Health and Disease Volume 1 represents a state-of-the-art work for researchers, physicians or professionals being interested in the biological phenomenon of cell fusion in physiological processes and beyond.