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Kurzbeschreibung

An adjuvant is an additive that enhances the effectiveness of a medical treatment. New technologies, including recombinant protein and DNA, have sparked advances in vaccine development and delivery systems. Advances in Vaccine Adjuvants and Delivery Systems addresses these issues and provides scientists designing vaccines with the information they need to select candidates to develop delivery systems.

 

Aus dem Inhalt

Contributors.

 

Preface.

 

Chapter 1. Development of vaccine adjuvants - a historical perspective (Gary Ott and Gary Van Nest).

 

Chapter 2. Antigen-Processing and Presentation (Subash Sad).

 

Chapter 3. Mechanisms of Adjuvant Action (Nils Lycke).

 

Chapter 4. Aluminum-containing Adjuvants: Properties, Formulation and Use (Stanley L. Hem and Harm HogenEsch).

 

Chapter 5. MF59: A Safe and Potent Oil in Water Emulsion Adjuvant (D.T. O'Hagan).

 

Chapter 6. TLR4 agonists as vaccine adjuvants (David A. Johnson and Jory R. Baldridge).

 

Chapter 7. Immunostimulatory CpG Oligodeoxynucleotides as Vaccine Adjuvants (Dennis M. Klinman, Debbie Currie and Hidekazu Shirota).

 

Chapter 8. Small Molecule Immunopotentiators as Vaccine Adjuvants (Fengfeng Xu, Nicholas M. Valiante, and Jeffrey B. Ulmer).

 

Chapter 9. New ISCOMs Meet Unsettled Vaccine Demands (Bror Morein, Kefei Hu, Karin Lövgren, and Erik Dhondt).

 

Chapter 10. Surface Charged Poly(lactide-co-glycolide) Microparticles as Novel Antigen Delivery Systems (Manmohan Singh, James Chesko, Jina Kazzaz and Derek T. O'Hagan).

 

Chapter 11. Liposomal Cytokines and Liposomes Targeted to Costimulatory Molecules as Adjuvants for HIV Subunit Vaccines (Bulent Ozpolat and Lawrence B. Lachman).

 

Chapter 12. Archaeosomes Vaccine Adjuvants for Cross-priming CD8+ T Cell Immunity (Lakshmi Krishnan and G. Dennis Sprott).

 

Chapter 13 Mucosal Adjuvants and Delivery Systems (Michael Vajdy).

 

Chapter 14. Cytokines as Vaccine Adjuvants (Nejat Egilmez).

 

Chapter 15. Polyphosphazenes as vaccine adjuvants (Alexander K. Andrianov).

 

Chapter 16. Vaccine Delivery by Transdermal Electroporation (Amit Misra).

 

Chapter 17. Nonclinical Safety Assessment of Vaccines, and the Evaluation of Novel Adjuvants and Delivery Systems (Jose A. Lebron, Jayanthi J. Wolf, Catherine V. Kaplanski, and Brian J. Ledwith).

 

Chapter 18. Safety Evaluation of Vaccine Adjuvants (Erik B. Lindblad).