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Zweigstelle: Hauptstelle	Standorte: ZB-100 74	Status: Verfügbar	Vorbestellungen: 0	Frist:	Barcode: 00257966	Lagepläne: Lageplan	Ausleihhinweis:

Cancer therapeutics include an ever-increasing array of tools at the disposal of clinicians in their treatment of this disease. However, cancer is a tough opponent in this battle, and current treatments, which typically include radiotherapy, chemotherapy and surgery, are not often enough to rid the patient of his or her cancer. Cancer cells can become resistant to the treatments directed at them, and overcoming this drug resistance is an important research focus. Additionally, increasing discussion and research is centering on targeted and individualized therapy. While a number of approaches have undergone intensive and close scrutiny as potential approaches to treat and kill cancer (signaling pathways, multidrug resistance, cell cycle checkpoints, anti-angiogenesis, etc.), other approaches have focused on blocking the ability of a cancer cell to recognize and repair the damaged DNA that primarily results from the front-line cancer treatments; chemotherapy and radiation.

 

This comprehensive and timely reference focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment.

TOC:

 

1. Introduction and Overview of Current Targets: Bench to Clinic

 

Mark R. Kelley

 

2. MGMT a Critical DNA Repair Gene Target for Chemotherapy Resistance

 

Stanton L. Gerson and Lili Liu

 

3. Blockade of Base Excision Repair: Inhibitionof Small Lesions Results in Big Consequences to Cancer Cells

 

Melissa Fishel and Carlo Vascotto

 

4. PARP Inhibitors - Scientific Rationale and Clinical Development for Cancer

 

Ruth Plummer, Nicola J. Curtin and Yvette Drew

 

5. Inhibiting Selective DNA Polymerases for Therapeutic Intervention

 

Anthony J. Berdis

 

6. Targeting the Nucleotide Excision Repair Pathway for Therapeutic Applications

 

John Turchi and Stephan M. Patrick

 

7. Homologous Recombination and ATM/ATR Targets

 

Henning Willers, Lee Zou and Heike N. Pfaffle

 

8. DNA Double Strand Break Repair by Nonhomologous End Joining and its Clinical Relevance

 

Michael Weinfeld and Susan Lees-Miller

 

9. Defective MMR-c-Abl-p73-GADD45alpha Expression in Cancer Chemoresistance

 

David Boothman and Long Shan Li

 

10. DNA Repair Signaling Targets

 

Susan Ashwell

 

11. Redox Regulation of DNA Repair and Therapeutic

 

Millie M. Georgiadis

 

12. Personalized Cancer Medicine: DNA Repair Alterations is a Promising Predictive Marker in Cancer

 

Srinivasan Madhusudan

 

13. The Role of DNA Damage and Repair in Neurotoxicity Caused by Cancer Therapies

 

Michael R. Vasko

 

14. Future Directions

 

Mark R. Kelley