Understanding antibiotic chemotherapy at the ecological level is necessary for more permanent advances in development and in the usage of antibiotic agents both old, new, and in the future. This book traces the history of bacteria, from the development of life on earth to the evolution of diversity. It is this diversity that led, almost automatically to the development of pathogens and predators. The relationship of pathogens and host lead to the development of antibiotics and resistance mechanism. Man has extended this process and we now have a situation in which new antibiotics only are effective for a short time. If we are to create long term antibiotics we must design them with this history in mind.
This book is intended for students at various levels that will be the microbiology researchers in the time to come. Also microbiology professors, particularly those teaching medical microbiology as well as physicians administering antibiotics daily and researchers in the pharmaceutical industry may find this book useful.
Table of contents
Preface
Legend to the frontispiece
Part 1 Origin Of Bacteria
1. Origin Of Life Based On Physical Principles
2. Preamble To Life
3. The First Cell
4. Development Of Cell Physiology And Diversity
Part 2 Wall Structure
5. Covalent Bonds And Tensile Strength Of Biomaterials
6. Structure Of The Fabric That Covers A Bacterium
7. The Covalently-Linked Sacculus: The Nona-Muropeptide Model
8. The Structure Of The Tessera : I.E. The Unit Structure Of The Wall Surface
9. Extrusion And Incorporation Into The Wall
10. The Role Of Poles In The Growth Strategy Of Bacteria
Part 3 Bacterial Morphologies
11. Sidewalls Of Gram-Negative Rod-Shaped Bacteria
12. Growth Strategies For Gram-Positive Cells
13. Wall Growth Strategies For Gram-Negative Cells
14. Commas, Vibrios, Spirilla, And Helicobacters; Tapered And Branched Bacteria
15. Spirochetes And Spiroplasma And The Special Strategies For CWD (Cell Wall Deficient) Cells
16. Coccal Versus Rods-Shaped Cell And The First Bacterium
17. Diseases: Old And New, Especially
Part 4 Antibiosis
18. Lysozymes As Alternatives To ß-Lactams Antibiotics Acting On The Bacterial Wall
19. Development Of Wall Antibiotics And Bacterial Counter-Measures
20. Antibiotics And Resistance, With An Emphasis On Aminoglycosides
21. Future Chemotherapy Aimed At The Bacterial Murein
References
Verfasserangabe:
by Arthur L. Koch
Jahr:
2007
Verlag:
Dordrecht [u.a.], Springer
Aufsätze:
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Monographien
ISBN:
9781402066252
2. ISBN:
1-4020-6625-2
Beschreibung:
X, 224 S. : Ill., graph. Darst.
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Sprache:
englisch||
Fußnote:
Literaturangaben
Mediengruppe:
Ausleihbestand