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Kurzbeschreibung

This new edition provides a basis for understanding cell cycle and growth control as it relates to biological regulation, with an emphasis on aberrations accompanying the onset and progression of cancer. It covers cellular, biochemical, molecular, and genetic approaches to investigating the control of processes in cell cycle. The fundamental principles, as well as the conceptual and experimental approaches to the study of proliferation, are presented, followed by detailed discussions of the applications to the diagnosis and treatment of cancer.

 

Aus dem Inhalt

Preface.

 

Contributors.

 

PART I.

 

1. Cell Fates (Arthur B. Pardee).

 

2. Architectural Organization of the Regulatory Machinery for Transcription, Replication and Repair: Dynamic Temporal-Spatial Parameters of Cell Cycle Control ( Corey D. Braastad, et al.).

 

PART II.

 

3. Cell Cycle Regulatory Cascades ( Heide L. Ford, et al.).

 

4. Membrane Receptors and Signal Transduction Pathways in G1: Regulation of Liver Regeneration and T Cell Proliferation (Joseph F. Porter and David T. Denhardt).

 

5. Onset of DNA Synthesis and S Phase ( G. Prem-Veer Reddy, et al.).

 

6. The Progression and Regulation of Mitotic Events (Greenfield Sluder, et al.).

 

7. Cell Cycle Inhibitory Proteins (Carmen Carneiro and Andrew Koff).

 

8. Chromatin Remodeling and Cancer (Cynthia J. Guidi and Anthony N. Imbalzano).

 

9. Extracellular Matrix: Tissue Specific Regulator of Cell Proliferation (Aylin Rizki and Mina J. Bissell).

 

10. Not yet arrived (Judah Folkman).

 

11. Regulation of Cell Growth, Differentiation, and Death During Metamorphosis (Hans Laufer and Eric H. Baehrecke).

 

12. Translational Control and the Cell Cycle (Robert E. Rhoads).

 

PART III.

 

13. Not yet arrived (Thea Tlsty).

 

14. Immortalisation by SV40 Large T Antigen (Rowena L. Martinet, et al.).

 

15. Apoptosis Signaling in Normal and Cancer Cells (Shulin Wang and Wafik S. El-Deiry).

 

PART IV.

 

16. Mutagenesis, Mutations, and DNA Repair (Roger D. Johnson).

 

17. Oncogenes (Stacey J. Baker and E. Premkumar Reddy).

 

18. Role of the Retinoblastoma Family in Cell Cycle Progression and Growth Control (Valeria Masciullo and Antonio Giordano).

 

19. p53 Tumor-Suppressor Genes (Faith A. Zamamiri-Davis and Gerard P. Zambetti).

 

PART V.

 

20. Cell Cycle and Growth Control: Current Clinical Applications (Michael Deininger).

 

PART VI.

 

21. Misregulated Fate--Cancer (Arthur B. Pardee).

 

Index.