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The first truly comprehensive book about peptidomics for protein and peptide analysis, Peptidomics: Methods and Applications offers a detailed description of the hows and whys of technique, and how it has evolved. It details methods and describes typical applications, including the use of peptidomics for drug discovery and toxicity analysis. The book provides information that is both sufficiently detailed to be a step-by-step guide for beginning researchers, while also being a reference for experienced professionals. The book explains the current state of the field, new developments now emerging, and examples of applications for fields from pharmaceutical science, to toxicity biomarkers, to neuroscience.

 

Aus dem Inhalt

SECTION 1: STUDIES OF NATURALLY OCCURRING PEPTIDES.

 

Chapter 1: Analysis of the peptidomes of amphibian skin granular gland secretions - an integrated functional genomic strategy (Chris Shaw, and Tianbao Chen).

 

Chapter 2: A short history of insect (neuro)peptidomics - A personal story of the birth and youth of an excellent model for studying peptidome biology (Peter D.E.M. Verhaert, Martijn W.H. Pinkse, Maria C. Prieto-Conaway, and Markus Kellmann).

 

Chapter 3: Peptidomics of short linear cytolytic peptides from spider venom (Sergey A. Kozlov, Alexander A. Vassilevski, and Eugene V. Grishin).

 

Chapter 4: Molecular cloning approaches to peptidomics: the identification of novel cDNAs encoding neurotoxin-like peptide pools (Zhensheng Pan, Richard Barry, and Mikhail Soloviev).

 

Chapter 5: Wheat antimicrobial peptides (Tatyana I. Odintsova, and Tsezi A. Egorov).

 

Chapter 6: Immunopeptidomics: Applications to dissect immune responses through proteomic-based approaches (Ernesto Oviedo-Orta, and Alexandra Bermudez-Fajardo).

 

Chapter 7: Strategies for reliable and improved identification of peptides (Karl Skuld, Maria Folth, Marcus Svensson, Anna Nilsson, Per Svenningsson, and Per E. Andrun).

 

SECTION 2: PEPTIDOMICS METHODS AND NEW DEVELOPMENTS.

 

Chapter 8: Peptidomics approach to proteomics (Petra Zarbig, and Harald Mischak).

 

Chapter 9: The importance of sample handling in neuropeptidomics (Karl Skuld, Marcus Svensson, Anna Nilsson, Maria Folth, Per Svenningsson, and Per E. Andrun).

 

Chapter 10: Affinity peptidomics and protein microarrays: application to forensics and biometrics (Julian Bailes, and Mikhail Soloviev).

 

Chapter 11: Selective depletion and enrichment methods for the analysis of protein and peptide pools (Paul Finch, and Mikhail Soloviev).

 

Chapter 12: Detection of target peptides in foods and feeds by mass spectrometry (Mireia Fernandez Ocaca).

 

Chapter 13: Quantification of Polypeptides by Mass Spectrometry (Pedro R. Cutillas).

 

SECTION 3: PEPTIDOMICS APPROACH TO BIOMARKER DISCOVERY.

 

Chapter 14: Biomarker discovery (Petra Zarbig, and Harald Mischak).

 

Chapter 15: Can peptidomics provide a useful approach for the identification of biomarkers of toxicological exposure or effect (Helen Griffiths)?

 

Chapter 16: Peptidomics in Neuroendocrine research: a Caenorhabditis elegans and Mus musculus study (Kurt Boonen, Steven J. Husson, Geert Baggerman, Anja Cerstiaens, Walter Luyten, and Liliane Schoofs).

 

CONCLUSION.

 

Chapter 17: Peptidomics and Biology: two scientific disciplines driving each other (Chris Shaw, and Peter D.E.M. Verhaert)