NF-B is a critical signaling molecule in the immune system that regulates cell survival and cell death, lymphocyte responses, and inflammation. Acting as a transcription factor that can receive several inputs, it coordinates distinct gene expression programs in response to a wide variety of stimuli.
Written and edited by experts in the field, this volume includes contributions covering the structure of NF-B, its DNA-binding activity and specificity, the role of the inhibitor I-B, and canonical and alternative mechanisms of NF-B activation. The contributors examine the physiological role of NF-B in immune cells, as well as its functions in other tissues, such as the nervous system. They also discuss work indicating that NF-B represents a critical link between inflammation and cancer.
Including clinical perspectives on the use of NF-B inhibitors in cancer therapy and a historical introduction by David Baltimore, in whose lab NF-B was discovered, this volume is a vital reference for cell and molecular biologists, immunologists, and pathologists interested in regulation of cell function.
Contents
Preface
Discovering NF-B
David Baltimore
The NF-B Family of Transcription Factors and Its Regulation
Andrea Oeckinghaus and Sankar Ghosh
Specification of DNA Binding Activity of NF-B Proteins
Fengyi Wan and Michael J. Lenardo
A Structural Guide to Proteins of the NF-B Signaling Module
Tom Huxford and Gourisankar Ghosh
The IKK Complex, a Central Regulator of NF-B Activation
Alain Israël
Ubiquitination and Degradation of the Inhibitors of NF-B
Naama Kanarek, Nir London, Ora Schueler-Furman, and Yinon Ben-Neriah
Signaling to NF-B: Regulation by Ubiquitination
Ingrid E. Wertz and Vishva M. Dixit
Selectivity of the NF-B Response
Ranjan Sen and Stephen T. Smale
Control of NF-B-dependent Transcriptional Responses by Chromatin Organization
Gioacchino Natoli
The Regulatory Logic of the NF-B Signaling System
Ellen O’Dea and Alexander Hoffmann
Oncogenic Activation of NF-B
Louis M. Staudt
NF-B as a Critical Link Between Inflammation and Cancer
Michael Karin
The Nuclear Factor NF-B Pathway in Inflammation
Toby Lawrence
Roles of the NK-B Pathway in Lymphocyte Development and Function
Steve Gerondakis and Ulrich Siebenlist
NF-B in the Immune Response of Drosophila
Charles Hetru and Jules A. Hoffmann
NF-B in the Nervous System
Barbara Kaltschmidt and Christian Kaltschmidt
Use of Forward Genetics to Discover Novel Regulators of NF-B
Tao Lu and George R. Stark
Index
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edited by Michael Karin ; Louis M. Staudt
Jahr:
2010
Verlag:
Cold Spring Harbor, NY, Cold Spring Harbor Laboratory Press
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Standort A002
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Monographien
ISBN:
9780879699024
2. ISBN:
0-87969-902-7
Beschreibung:
VIII, 271 S. : Ill., graph. Darst.
Sprache:
englisch||
Fußnote:
Liteaturangaben
Mediengruppe:
Ausleihbestand