Genetic Association Studies is designed for students of public health, epidemiology, and the health sciences, covering the main principles of molecular genetics, population genetics, medical genetics, epidemiology and statistics. It presents a balanced view of genetic associations with coverage of candidate gene studies as well as genome-wide association studies. All aspects of a genetic association study are included, from the lab to analysis and interpretation of results, but also bioinformatics approaches to causality assessment. The role of the environment in genetic disease is also highlighted. Genetic Association Studies will enable readers to understand and critique genetic association studies and set them on the way to designing, executing, analyzing, interpreting, and reporting their own.
Features
Focuses on two types of genetic association studies: candidate gene studies and genomewide association studies
A non-mathematical approach to explain data analysis methods
Coverage of genotyping methods
Inclusion of a post-GWAS bioinformatics approach to analysing statistical results
Consideration of the environment as an important player in disease genetics
Includes the use of association studies in medical practice and genetic risk profiling
TOC:
1. Primer on Molecular Genetics
2. Primer on Medical Genetics
3. Primer on Population Genetics
4. Epidemiologic Principles and Genetic Association Studies
5. Environmental Epidemiology in the Context of Genetic Epidemiology
6. Elementary Statistical Concepts
7. Genotyping Methods and Errors
8. Candidate Gene Studies and Genome-Wide Association Studies
9. Statistical Analysis of Genetic Association Study Results
10. Bioinformatics for the Interpretation of Genetic Association Study Results
11. Genetic Risk Profiling and Medical Applications of Genetic Associations
Verfasserangabe:
Mehmet Tevfik Dorak
Jahr:
2017
Verlag:
New York, NY, Garland Science
Aufsätze:
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Regalstandort W0.40
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Systematik:
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ME-40, GE-10
Interessenkreis:
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Monographien
ISBN:
978-0-8153-4463-6
2. ISBN:
0-8153-4463-5
Beschreibung:
230 Seiten : Diagramme, Illustrationen
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Sprache:
Englisch
Mediengruppe:
Ausleihbestand