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The innate immune system is rapidly activated in response to infection and injury. It is a generic rather than pathogen-specific response that recruits immune cells, promotes inflammation, and mobilizes the adaptive immune system. Excessive or chronic inflammation may cause tissue damage, so a careful balance is required to restore homeostasis.

 

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews the cellular and molecular mechanisms involved in innate immunity and all types of inflammation. The contributors examine the cell types that make up the innate immune system, their use of pattern recognition receptors (e.g., Toll-like receptors) to identify pathogens and damaged tissues, and how they trigger signaling pathways that culminate in inflammation, pathogen destruction, and tissue repair. The numerous chemical signals and factors involved in innate immunity and inflammation are described, as are those that keep inflammation in check.

 

The authors also discuss the diseases that can result when these processes go awry, such as rheumatoid arthritis and cancer. This volume is therefore a valuable reference for all immunologists, cell biologists, and medical scientists wishing to understand these protective processes and their implications for human health and disease.

Contents

Preface

Microbial Sensing by Toll-Like Receptors and Intracellular Nucleic Acid Sensors

Surya Pandey, Taro Kawai, and Shizuo Akira

Emerging Principles Governing Signal Transduction by Pattern-Recognition Receptors

Jonathan C. Kagan and Gregory M. Barton

Transcriptional Control of Inflammatory Responses

Stephen T. Smale and Gioacchino Natoli

Inflammasomes

Marcel R. de Zoete, Noah W. Palm, Shu Zhu, and Richard A. Flavell

Tumor Necrosis Family Superfamily in Innate Immunity and Inflammation

John ?ed?, Vasileios Bekiaris, and Carl F. Ware

IL-6 in Inflammation, Immunity, and Disease

Toshio Tanaka, Masashi Narazaki, and Tadamitsu Kishimoto

The Chemokine System in Innate Immunity

Caroline L. Sokol and Andrew D. Luster

Lipid Mediators in the Resolution of Inflammation

Charles N. Serhan, Nan Chiang, Jesmond Dalli, and Bruce D. Levy

DNA Degradation and Its Defects

Kohki Kawane, Kou Motani, and Shigekazu Nagata

Group 2 Innate Lymphoid Cells in Health and Disease

Brian S. Kim and David Artis

Allergic Inflammation—Innately Homeostatic

Laurence E. Cheng and Richard M. Locksley

Inflammation and the Blood Microvascular System

Jordan S. Pober and William C. Sessa

Sinusoidal Immunity: Macrophages at the Lymphohematopoietic Interface

Siamon Gordon, Annette Plüddemann, and Subhankar Mukhopadhyay

Approaching the Next Revolution? Evolutionary Integration of Neural and Immune Pathogen Sensing and Response

Kevin J. Tracey

Index