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Inhaltsverzeichnise (Kurzversion) - Table of Contents (short version)

 

Introduction

The Almost Forgotten Fifth Nucleotide in DNA: An Introduction

 Pattern Formation

Replication and Translation of Epigenetic Information

 DNA Methyltransferases. Facts, Clues, Mysteries

 DNA Methylation in Plants

 Determinant of Promoter Activity

DNA Methylation: De novo Methylation, Long-term Promoter Silencing, Methylation Patterns in the Human Genome, and Consequences of Foreign DNA Insertion

 DNA Methyltransferases

Establishment and Maintenance of DNA Methylation Patterns in Mammals

 Molecular Enzymology of Mammalian DNA Methyltransferases

 Epigenetic Phenomena

Familial Hydratidiform Molar Pregnancy: the Germline Imprinting Defect Hypothesis

 Dual Inheritance

 Mutagenesis and Repair

Mutagenesis at Methylated CpG Sequences

 Cytosine Methylation and DNA Repair

 Subject Index.

 

Thema

methyltransferase; epigenetic information; human genome; methylation patterns; cytosine methylation; dual inheritance system; Science-Titel (SC)

 

Beschreibung

The structural and functional importance of the correct patterns of DNA methylation in all parts of a mammalian genome is, unfortunately, not well understood. The stability, inheritability, and developmental flexibility of these patterns all point to a major role that these patterns appear to play in determining structure and funtion of the genome. Up to the present time, studies on the repetitive sequences, which comprise more than 90 per cent of the DNA sequences in the human or other genomes, have been neglected.