Zweigstelle	Standorte	Status	Vorbestellungen	Frist	Barcode	Lageplan	Ausleihhinweis
Zweigstelle: Dauerleihe	Standorte: NA-30 171	Status: Entliehen	Vorbestellungen: 0	Frist: 10.09.2023	Barcode: 00188972	Lagepläne: Lageplan	Ausleihhinweis:

he number of protein isoforms in proteomes can be two to three orders of magnitude higher than the number of genes in the genomes. This is in large part due to posttranslational modifications of proteins that provide covalent alterations to protein backbones and side chains that increase proteome complexities. Greater than 5% of the genes in the human genome encode enzymes that perform such modifications, including hundreds of protein kinases and opposing phosphatases, ubiquitinyl ligases, acetylases and deacetylases, methyl transferases and glycosyl transferases. The major classes of posttranslational modifications (PTM) are codified according to types of residues modified, underlying chemistry, PTM catalysts, and biological consequences. This is the first comprehensive treatment of this burgeoning area of proteome diversification.

Table of Contents

Preface

1 Introduction

2 Phosphorylation and dephosphorylation

3 Sulfurylation of proteins

4 Sulfur redox transformations in proteins

5 Protein methylation

6 Protein acetylation

7 Lipid modifications of proteins

8 Posttranslational proteolysis

9 Ubiquitin and ubiquitin like protein tags

10 Protein glycosylation

11 ADP ribosylation of proteins

12 Protein hydroxylation

13 Automodification reactions of proteins

14 Swinging arms for covalent tethering

of coenzymes

15 Protein carboxyaltion and amidation

 

References

Index