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Foreword: Thomas K. Hunt.

 

Introduction: Raphael C. Lee, Florin Despa, and Kimm J. Hamann.

 

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Part I: Cell Structure and Integrity:.

 

1. Biological Water: Its Vital Role in Macromolecular Structure and Function: Florin Despa.

 

2. Thermal Stability of Proteins: John C. Bischof and Xiaoming He.

 

3. The Physics of the Interactions Governing Folding and Association of Proteins: Weihua Guo, Joan-Emma Shea, and R Stephen Berry.

 

4. Molecular Crowding Effects on Protein Stability: Florin Despa, Dennis P. Orgill, and Raphael C. Lee.

 

Part II: Modes of Cell Injury:.

 

5. Mechanical Cell Injury: Kenneth A. Barbee.

 

6. Cell Injury by Electric Forces: Raphael C. Lee.

 

7. Electroconformational Denaturation of Membrane Proteins: Wei Chen.

 

8. Heat Injury to Cells in Perfused Systems: Dennis P. Orgill, Stacy A. Porter, and Helena O. Taylor.

 

9. Cryo-Injury and Biopreservation: Alex Fowler and Mehmet Toner.

 

10. Oxidative Reactive Species in Cell Injury: Mechanisms in Diabetes Mellitus and Therapeutic Approaches: Leonid E. Fridlyand and Louis H. Philipson.

 

Part III: Cellular Responses to Injury:.

 

11. The Mechanisms of Cell Membrane Repair: A Tutorial Guide to Key Experiments: Richard A. Steinhardt.

 

12. The Role of Ca2+ in Muscle Cell Damage: Hanne Gissel.

 

13. Protein Denaturation and Aggregation: Cellular Responses to Denatured and Aggregated Proteins: Stephen C. Meredith.

 

14. Thermally Induced Injury and Heat-Shock Protein Expression in Cells and Tissues: Marissa Nichole Rylander, Yusheng Feng, Jon Bass, and Kenneth R. Diller.

 

15. Cellular Response to DNA Damage: Johnny Kao, Barry S. Rosenstein, Sheila Peters, Michael T. Milano, and Stephen J. Kron.

 

16. Autophagy: Ameeta Kelekar.

 

17. Magnetic Resonance Imaging of Changes in Muscle Tissues after Membrane Trauma: Hanne Gissel, Florin Despa, John Collins, Devkumar Mustafi, Katherine Rojahn, Greg Karczmar, and Raphael Lee.

 

Part IV: Therapeutics for Cell Injury:.

 

18. Na+-K+ Pump Stimulation Improves Contractility in Damaged Muscle Fibers: Torben Clausen.

 

19. Multimodal Strategies for Resuscitating Injured Cells: Jayant Agarwal, Alexandra Walsh, and Raphael C. Lee.

 

20. Membrane Sealing by Polymers: Stacey A. Maskarinec, Guohui Wu, and Ka Yee C. Lee.

 

21. A Surfactant Copolymer Facilitates Functional Recovery of Heat-Denatured Lysozyme: Alexandra M. Walsh, Devkumar Mustafi, Marvin W. Makinen, and Raphael C. Lee.

 

Index of Contributors