About this book
Nearly ten years after they published the first book devoted entirely to the Leydig cell, Matthew Hardy and Anita Payne have collaborated again to provide a comprehensive study of this fascinating and important cell type. Their book presents all of the developments in our understanding of Leydig cell biology and explores a wide variety of current and potential clinical applications. All aspects of Leydig cell biology, development, regulation, and physiology are explored in thirty-one expertly written chapters. The book explores topics of great interest to the private sector, including the possible application of steroidogenesis discoveries to androgen synthesis or suppressing Leydig cell function as a key mechnanism in the development of a male contraceptive.
This in-depth volume is an invaluable resource for information on the science and application of Leydig cell biology and function.
Table of contents
The Leydig Cell
HISTORICAL
1. A History of Leydig Cell Research. A. Kent Christensen, University of Michigan. akc@umich.edu
CELL BIOLOGY
2. Structural and Histological Analysis of Leydig Cell Steroidogenic Function. Syed G. Haider, Gisela Servos, and Nicole Tran, Heinrich Heine University, Duesseldorf, Germany. haider@uni-duesseldorf.de
3. Fetal Leydig Cells: Origin, Regulation And Steroidogenesis. Humphrey Hung-Chang Yao and Ivraym Barsoum, University of Illinois. hhyao@uiuc.edu
4. Regulation Of Leydig Cells During Pubertal Development. Renshan Ge and Matthew P. Hardy, Population Council. hardy@popcbrockefeller.edu
5. The Human Leydig Cell: Functional Morphology and Developmental History. Frederick P. Prince, Plymouth State College. fprince@mail.plymouth.edu
6. Dynamics of Leydig Cell Regeneration after EDS: A Model for Postnatal Leydig Cell Development. Katja J. Teerds and Eddy Rijntjes, Wageningen University Wageningen, The Netherlands. katja.teerds@wur.nl
7. Aging and the Decline of Androgen Production. Haolin Chen, Andrew Midzak, Lindi Luo and Barry R. Zirkin, Johns Hopkins University. brzirkin@jhsph.edu
STEROIDOGENESIS
8. Regulation of Leydig Cell Cholesterol Metabolism. Salman Azhar and Eve Reaven, GRECC, VA Hospital,
Palo Alto, CA. salman.azhar@med.va.gov
9. The Role of StAR in Leydig Cell Steroidogenesis. Douglas M. Stocco, Texas Tech
University. Doug.Stocco@ttuhsc.edu
10. Steroidogenic Enzymes in Leydig Cells. Anita H. Payne, Stanford University School of Medicine. Anita.Payne@stanford.edu
11. Development of Leydig Cell Steroidogenesis. Peter J. O'Shaughnessy, Heather Johnston, and Paul Joseph Baker, Institute of Comparative Medicine, University of Glasgow Veterinary School, Glasgow, UK. P.J.OShaughnessy@vet.gla.ac.uk
12. Peripheral Testosterone Metabolism. Daniel P. Sherbet and Richard Auchus, University of Texas Southwestern, Division of Endocrinology and Metabolism. Richard.auchus@utsouthwestern.edu
13. Leydig Cell Aromatase: From Gene To Physiology. Serge Carreau, University of Caen, France. carreau@ibfa.unicaen.fr
14. The Role of Estrogen Sulfotransferase (SULT1E1) in Leydig Cells. Wenchau Song,Dept.
Pharmacology, University of Pennsylvania. song@spirit.gcrc.upenn.edu
15. Endocrinology of Leydig Cells in Nonmammalian Vertebrates. Kelly Bonner Engel and Gloria Callard, Boston University. gvc@bu.edu
REGULATION
16. The Luteinizing Hormone Receptor. Maria Dufau and Chon-Hwa Tsai-Morris, National Institutes of Health, dufaum@mail.nih.gov
17. Insights into Leydig Cell Function from Mice with Genetically Modified Gonadotropin Action. Ilpo Huhtaniemi, Institute of Reproductive and Developmental Biology, Imperial College London, U.K. ilpo.huhtaniemi@imperial.ac.uk
18. Growth Factors in Leydig Cell Function. Varadaraj Chandrashekar and Andrej
Bartke. Southern Illinois University, Carbondale. shekar@siu.edu , abartke@siumed.edu
19. The biology of Insulin-like peptide 3 (INSL3) in Leydig cells. Richard Ivell & Ross AD Bathgate. Richard Ivell and Ross A.D. Bathgate. Ivell: School of Molecular and Biomedical Science, University of Adelaide, Frome Road, SA 5005, Australia. Richard.ivell@Adelaide.edu.au . Bathgate: Howard Florey Institute,
University Melbourne, Parkville, VIC 3010, Australia. bathgate@mail.hfi.unimelb.edu.au
20. Neuronal Signaling Molecules and Leydig Cells. Artur Mayerhoffer, Department of Molecular Anatomy, Technical University of Munich, mayerhofer@lrz.uni-muenchen.de
21. Regulation of Leydig Cell Function as it pertains to the Inflammatory Response.
Dale B. Hales, University of Illinois, Chicago, Il. dbhale@uic.edu
22. Activins And Leydig Cell Development, Differentiation And Disease. Gail P. Risbridger and Christopher Butler, Monash Medical Center, Institute of Reproduction, Victoria, Australia. gail.risbridger@med.monash.edu.au
23. Nuclear Transcription Factors as Master Regulators of Gene Expression Controlling Leydig Cell Development and Physiology. Jaques Tremblay, Universite Laval, Quebec, Canada. jacques-J.tremblay@crchul.ulaval.ca
24. Androgen Receptor in Leydig Cell Function and Development. Stephen M. Eacker and Robert E. Braun, Robert E. Braun, University of Washington, Seattle, WA.
braun@u.washington.edu
PHYSIOLOGY AND APPLIED ASPECTS
25. Fluid Exchange and Transport of Hydrophilic Factors in the Testis. Brian Setchell,
Department of Anatomical Sciences, University of Adelaide, Adelaide, SA 5005, Australia.
brian.setchell@adelaide.edu.au
26. Immortalized Leydig Cell Lines as Models for Studying Leydig Cell Physiology. Mario
Ascoli, University of Iowa College of Medicine, Iowa City, IA. mario-ascoli@uiowa.edu
27. Induction of Leydig Cell Tumors by Xenobiotics. Paul Foster, National Institutes of Health. foster2@niehs.nih.gov
28. Environmental Factors that Disrupt Leydig Cell Steroidogenesis. Vassilios Papadopoulos, Georgetown University Medical Center. papadopv@georgetown.edu
29. The Leydig Cell as a Target for Hormonal Contraception. Craig Marc Luetjens, Joachim Wistuba, Gerhard Weinbauer, and Eberhard Nieschlag, Institute of Reproductive Medicine of the University Domagkstr, Muenster, Germany. eberhard.nieschlag@ukmuenster.de
30. Clinical Evaluation of Leydig Cell Function. Ronald S. Swerdloff and Christina Wang. Division of Endocrinology, Harbor-UCLA Medical Center, Torrance, CA. swerdloff@labiomed.org; wang@labiomed.org