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1402060157

 

Molecular Mechanisms of Cancer

Weber, Georg F.

2007, XIV, 650 p., Hardcover

ISBN: 978-1-4020-6015-1

 

 

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About this textbook

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Table of contents

Table of contents

 

CONDENSED TABLE OF CONTENTS

 

Introduction

 

Section I. General Mechanisms Of Transformation

 

1. Theories of Carcinogenesis

 

2. Physiologic Correlates of Malignancy

 

Section II. Alterations Intrinsic to the Tumor Cells

 

3. Cell Division and Survival

 

4. Cellular Senescence

 

5. Invasiveness

 

Section III. Mechanisms of Regulation Of Cancer Related Genes

 

6. DNA Repair

 

7. Epigenetic Regulation of Cancer Associated Gene Products

 

8. Interaction of the Groups of Cancer Related Gene Products

 

Section IV. Interactions between Host and Tumor

 

9. Structural Growth Control

 

10. The Organ Preference of Metastasis Formation

 

11. Angiogenesis

 

12. Interactions with The Immune System

 

13. Endocrine Dysregulation

 

14. Dormancy and Minimal Residual Disease

 

Section V. Molecular Mechanisms of Individual Cancers

 

15. Epithelial Tumors

 

16. Hematologic Malignancies

 

17. Mesenchymal Tumors

 

18. Neurologic Tumors

 

19. Tumors of Serous Cavities

 

20. Embryonic Tumors

 

About this textbook

 

The knowledge of molecular defects that lead to cancer is increasing rapidly. This has created a need for a textbook that conveys a comprehensive review of this topic. This book describes molecular processes whose deregulation is important in the formation of tumors. The material is developed from basic cell signalling pathways to their roles in the clinical manifestation of specific cancers. Topics covered include molecular events intrinsic to tumor cells (leading to growth deregulation, extended lifespan, and the ability to invade surrounding tissue), protective mechanisms that prevent transformation (including DNA repair and epigenetic regulation), tumor-host interactions (with the endocrine system, the immune system, and blood vessel formation), and the underlying molecular defects of individual cancers.

 

This book is an essential resource for researchers, graduate students and oncologists. It will also aid in drug discovery by identifying molecular targets. The growing insight generated by research into molecular carcinogenesis and the absence of comparably comprehensive and systematic textbooks makes this publication important and timely.