The MYC gene family plays essential roles in normal development and in multiple cellular functions. Moreover aberrant MYC gene activation is profoundly involved in the etiology of a wide range of cancers. MYC encodes a transcriptional regulator that modulates expression of genes controlling cell growth, proliferation, metabolism, differentiation, and death. Deregulation of these expression programs has been linked to MYC’s function in tumor initiation, progression, and survival.
Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers all aspects of MYC biology. The contributors discuss its normal functions in the control of cell growth, cell competition, pluripotency, and development, as well as the molecular basis for the effects of the MYC protein on transcription. In addition, they examine how MYC interacts with other proteins, induces apoptosis, and impacts metabolism, genomic stability, and microRNA expression.
The authors also provide a detailed analysis of the role of MYC in tumor initiation and progression. Its involvement in cancers such as medulloblastoma, neuroblastoma, and Burkitt’s lymphoma is examined, as are the prospects for anti-MYC therapies in cancer treatment. This book is essential reading for all cancer biologists, as well as researchers studying the regulation of gene expression.
Contents
TOC:
Preface
An Overview of MYC and Its Interactome
Maralice Conacci-Sorrell, Lisa McFerrin, and Robert N. Eisenman
MYC Cofactors: Molecular Switches Controlling Diverse Biological Outcomes
Stephen R. Hann
Genome Recognition by MYC
Arianna Sab? and Bruno Amati
Cellular MYCro Economics: Balancing MYC Function with MYC Expression
David Levens
MYC and Transcription Elongation
Peter B. Rahl and Richard A. Young
The Role of MIZ-1 in MYC-Dependent Tumorigenesis
Katrin E. Wiese, Susanne Walz, Björn von Eyss, Elmar Wolf, Dimitris Athineos, Owen Sansom, and Martin Eilers
MYC Degradation
Amy S. Farrell and Rosalie C. Sears
MYC Regulation of Cell Growth through Control of Transcription by RNA Polymerases I and III
Kirsteen J. Campbell and Robert J. White
MYC and the Art of MicroRNA Maintenance
James N. Psathas and Andrei Thomas-Tikhonenko
Control of Vertebrate Development by MYC
Peter J. Hurlin
Roles for MYC in the Establishment and Maintenance of Pluripotency
James Chappell and Stephen Dalton
Myc Function in Drosophila
Peter Gallant
Socializing with MYC: Cell Competition in Development and as a Model for Premalignant Cancer
Laura A. Johnston
MYC, Metabolism, Cell Growth, and Tumorigenesis
Chi V Dang
MYC and Mitochondrial Biogenesis
Fionnuala Morrish and David Hockenbery
Coordination of Nutrient Availability and Utilization by MAX- and MLX-Centered Transcription Networks
John M. O’Shea and Donald E. Ayer
MYC and the Control of Apoptosis
Steven B. McMahon
c-MYC-Induced Genomic Instability
Alexandra Kuzyk and Sabine Mai
MYC and the Control of DNA Replication
David Dominguez-Sola and Jean Gautier
MYC Activation Is a Hallmark of Cancer Initiation and Maintenance
Meital Gabay, Yulin Li, and Dean W. Felsher
Oncogenic Mechanisms in Burkitt Lymphoma
Roland Schmitz, Michele Ceribelli, Stefania Pittaluga, George Wright, and Louis M. Staudt
Role of MYC in Medulloblastoma
Martine F. Roussel and Giles W. Robinson
Neuroblastoma and MYCN
Miller Huang and William A. Weiss
MYC Association with Cancer Risk and a New Model of MYC-Mediated Repression
Michael D. Cole
Synthetic Lethal Screens as a Means to Understand and Treat MYC-Driven Cancers
Silvia Cermelli, In Sock Jang, Brady Bernard, and Carla Grandori
Therapeutic Strategies to Inhibit MYC
Michael R. McKeown and James E. Bradner
Index