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The “Gold Standard” in Biochemistry text books. Biochemistry 4e, is a modern classic that has been thoroughly revised. Don and Judy Voet explain biochemical concepts while offering a unified presentation of life and its variation through evolution. Incorporates both classical and current research to illustrate the historical source of much of our biochemical knowledge.

New to this edition:

•Many new and updated protein and nucleic acid structures

•Next generation DNA sequencing technologies

•New methods of protein structure prediction and design

•Discussion of glycomics

•How transmembrane proteins are inserted into membranes

•Updated discussions on vesicle formation and fusion

•Mechanism of nitric oxide synthase

•Structural characterization of G protein-coupled receptors

•Structures of (Na+-K+)-, Ca2+-, and (H+-K+)-ATPases

•ABC Transporters

•Voltage-gated ion channels

•Structures of all components of the electron transport system

•Structures of photosystems I and II

•Structures of fatty acid synthases

•Structure of topoisomerase II

•Mechanism of helicases

•Updated mechanisms of DNA replication

•DNA replication initiation

•Replication of mitochondrial DNA

•Mechanism of recombination

•Structure and mechanism of RecBCD

•Structure and mechanism of RNA polymerase II

•Structure and mechanism of Rho factor

•Structure of a group I intron

•Functions of RNAi

•Mechanism of ribosomal polypeptide synthesis

•Mechanism of DNA loading in phage heads

•Structure of chromatin