A comprehensive compendium of scholarly contributions relating to bacterial virulence gene regulation.
• Provides insights into global control and the switch between distinct infectious states (e.g., acute vs. chronic).
• Considers key issues about the mechanisms of gene regulation relating to: surface factors, exported toxins and export mechanisms.
• Reflects on how the regulation of intracellular lifestyles and the response to stress can ultimately have an impact on the outcome of an infection.
• Highlights and examines some emerging regulatory mechanisms of special significance.
• Serves as an ideal compendium of valuable topics for students, researchers and faculty with interests in how the mechanisms of gene regulation ultimately affect the outcome of an array of bacterial infectious diseases.
Table of Contents
I. Global Changes during and between Different states of Infections
1. Factors That Impact Pseudomonas aeruginosa Biofilm Structure and Function • 3
Boo Shan Tseng and Matthew R. Parsek
2. Chronic versus Acute Pseudomonas aeruginosa Infection States • 21
Barbara I. Kazmierczak and Thomas S. Murray
3. Quorum Sensing in Burkholderia • 40
Charlotte D. Majerczyk, E. Peter Greenberg, and Josephine R. Chandler
4. Staphylococcus aureus Pathogenesis and Virulence Factor Regulation • 58
Victor J. Torres, Meredith A. Benson, and Jovanka M. Voyich
5. Regulation of Virulence by Iron in Gram-Positive Bacteria • 79
Allison J. Farrand and Eric P. Skaar
6. Iron Regulation and Virulence in Gram- Negative Bacterial Pathogens with Yersinia pestis as a Paradigm • 106
Robert D. Perry and Kathleen A. McDonough
II. Adherence, Colonization, and Surface Factors
7. Uropathogenic Escherichia coli Virulence and Gene Regulation • 135
Drew J. Schwartz and Scott J. Hultgren
8. Phasevarions: an Emerging Paradigm in Epigenetic Gene Regulation in Host-Adapted Mucosal Pathogens • 156
Yogitha N. Srikhanta, Ian R. Peak, and Michael P. Jennings
9. Regulation of Exopolysaccharide Biosynthesis in Pseudomonas aeruginosa • 171
Yuta Okkotsu, Christopher L. Pritchett, and Michael J. Schurr
10. Regulation of Pneumococcal Surface Proteins and Capsule • 190
Abiodun D. Ogunniyi and James C. Paton
11. Regulation of Lipopolysaccharide Modifications and Antimicrobial Peptide Resistance • 209
Erica N. Kintz, Daniel A. Powell, Lauren Hittle, Joanna B. Goldberg, and Robert K. Ernst
III. Toxins and Associated Virulence Factor Production
12. Toxin and Virulence Regulation in Vibrio cholerae • 241
Karen Skorupski and Ronald K. Taylor
13. Virulence Gene Regulation in Bacillus anthracis and Other Bacillus cereus Group Species • 262
Jennifer L. Dale and Theresa M. Koehler
14. Regulation of Extracellular Toxin Production in Clostridium perfringens • 281
Jackie K. Cheung, Lee-Yean Low, Thomas J. Hiscox, and Julian I. Rood
15. Regulation of Toxin Production in Clostridium difficile • 295
Glen P. Carter, Kate E. Mackin, Julian I. Rood, and Dena Lyras
16. Anthrax and Iron • 307
Paul E. Carlson, Jr., Shandee D. Dixon, and Philip C. Hanna
IV. Protein Export and Intracellular Life within the Host
17. Regulation of the Expression of Type III Secretion Systems: an Example from Pseudomonas aeruginosa • 317
Audrey Le Gouellec, Benoit Polack, Dakang Shen, and Bertrand Toussaint
18. Regulation of Bacterial Type IV Secretion • 335
Jenny A. Laverde-Gomez, Mayukh Sarkar, and Peter J. Christie
19. PrfA and the Listeria monocytogenes Switch from Environmental Bacterium to Intracellular Pathogen • 363
Bobbi Xayarath and Nancy E. Freitag
20. The SsrAB Virulon of Salmonella enterica • 386
Sandra Billig, Alfonso Felipe-López, and Michael Hensel
21. Francisella tularensis: Regulation of Gene Expression, Intracellular Trafficking, and Subversion of Host Defenses • 402
Nrusingh P. Mohapatra, Shipan Dai, and John S. Gunn
V. Stress Response during Infection
22. Regulation of Salmonella Resistance to Oxidative and Nitrosative Stress • 425
Calvin A. Henard and Andrés Vázquez-Torres
23. Regulation of Vesicle Formation • 441
Aimee K. Wessel, Gregory C. Palmer, and Marvin Whiteley
24. Regulation of Envelope Stress Responses by Mycobacterium Tuberculosis • 465
Daniel J. Bretl and Thomas C. Zahrt
VI. Emerging Regulatory Mechanisms of Special Significance
25. Regulatory Mechanisms of Special Significance: Role of Small RNAs in Virulence Regulation • 493
Kai Papenfort, Colin P. Corcoran, Sanjay K. Gupta, Masatoshi Miyakoshi, Nadja Heidrich, Yanjie Chao, Kathtrin S. Fröhlich, Cynthia M. Sharma,
Wilma Ziebuhr, Alex Böhm, and Jörg Vogel
26. Negative Regulation during Bacterial Infection • 528
Andrew M. Stern, Ansel Hsiao, and Jun Zhu
27. Regulation in Response to Host-Derived Signaling Molecules • 545
Charley Gruber and Vanessa Sperandio
28. Regulating the Transition of Vibrio cholerae out of the Host • 566
EmilyKate McDonough, Evan Bradley, and Andrew Camilli