Table of Contents
1. INTRODUCTION
1 Introduction, Mary Ellen Sanders
2. BASIC BIOLOGY
2.1. The Indigenous Microbiota
2 Role of the Indigenous Microbiota in Health and Disease, Gerald W. Tannock
2.2. Biology of Effector Organisms for Probiotic and Replacement Therapy
3 Lactobacilli, Covadonga Barbés
4 Bifidobacteria: the Model Human Gut Commensal, Marco Ventura, Francesca Turroni, Angela Ribbera, Elena Foroni, and Douwe van Sinderen
5 Saccharomyces spp., Xinhua Chen and Ciarán P. Kelly
6 Streptococci as Effector Organisms for Probiotic and Replacement Therapy, John R. Tagg, Jeremy P. Burton, Philip A. Wescombe, and Chris N. Chilcott
7 Escherichia coli, Michael Schultz
8 Formulation, Administration, and Delivery of Probiotics, Kasipathy Kailasapathy
2.3. Prebiotics and Functional Carbohydrates
9 Introduction to Prebiotics, Helena M. R. T. Parracho, Delphine M. Saulnier, Anne L. McCartney, and Glenn R. Gibson
10 Human Milk Oligosaccharides as Prebiotics, Giovanni V. Coppa and Orazio Gabrielli
11 Inulin-Type Fructans, Jan Van Loo and Douwina Bosscher
12 Resistant Starch as a Prebiotic, Anthony R. Bird and David L. Topping
13 Effects of Prebiotic Supplementation on Bone Mineral Metabolism and Weight in Humans, Steven A. Abrams
14 Prebiotics and Lipid Metabolism, Nathalie M. Delzenne, Patrice D. Cani, and Audrey M. Neyrinck
2.4. Genomics of Lactic Acid Bacteria
15 Functional Genomics of Lactic Acid Bacteria, Tri Duong and Todd R. Klaenhammer
2.5. Proteomics of Lactic Acid Bacteria
16 Proteomic Approaches To Study Lactic Acid Bacteria, David P. A. Cohen, Elaine E. Vaughan, Willem M. de Vos, and Erwin G. Zoetendal
3. THERAPEUTIC MICROBIOLOGY IN HUMAN MEDICINE
3.1. Probiotics
17 Probiotics in Human Medicine: Overview, Jennifer K. Spinler and James Versalovic
18 Probiotics and Other Organisms in Allergy and Autoimmune Diseases, G. A. W. Rook and Nina Witt
19 Probiotics in Oral Biology and Dentistry, J. H. Meurman
20 Probiotics in Gastrointestinal Diseases, Francisco Guarner
21 Probiotics and Diseases of the Genitourinary Tract, Gregor Reid
22 Probiotics in Neurology and Psychiatry, Paul Forsythe and John Bienenstock
3.2. Prebiotics
23 Prebiotics in Human Medicine, Ian Rowland
3.3. Synbiotics
24 Synbiotics in Human Medicine, Stig Bengmark
4. THERAPEUTIC MICROBIOLOGY IN VETERINARY MEDICINE
25 Strategies for Altering the Intestinal Microbiota of Animals, Sergey R. Konstantinov and Jerry Wells
26 Probiotics in Veterinary Medicine, J. Scott Weese, Shayan Sharif, and Alex Rodiguez-Palacios
27 Prebiotics and Synbiotics in Companion Animal Science, David Hernot, Eva Ogué, George Fahey, and Robert A. Rastall
5. VIRAL STRATEGIES
28 Phage Therapy, Mikael Skurnik, Saija Kiljunen, and Maria Pajunen
6. FUTURE PROSPECTS
29 The Road Ahead: a Look at the Future, James Versalovic and Michael Wilson
The indigenous microbiota of humans and other animals, far from being passive bystanders, participate in a wide range of complex interactions with their host. The burgeoning field of therapeutic microbiology concerns itself with the manipulation of the indigenous microbiota in order to promote the health of the host. Providing a state-of-the-art overview of the field, this volume breaks new ground in explaining the breakthroughs possible with therapeutic microbiology.
The first volume of its kind in the field, Therapeutic Microbiology explores the potential and actual uses of the many methods for altering the microbiotas of humans and animals: probiotics, prebiotics, synbiotics, bacteriophages, and replacement therapy. It describes the biological principles underlying the manipulation of the indigenous microbiota and the biology of the effector organisms that have been utilized for this purpose. The many microbes that can potentially be used therapeutically and prophylactically are discussed at length. The book describes applications in both human and veterinary medicine, dentistry, neurology, immunology, and more.
This volume will serve as an important reference source for all those interested in this fast-moving field. Additionally, this book will be invaluable to medical, dental and veterinary practitioners with an interest in alternative approaches to the prevention and treatment of microbial diseases.