Abstract:
Cytokines in the Genesis and Treatment of Cancer provides a comprehensive picture of the dual role of host responses in promoting and inhibiting tumor progression. This volume represents an important investigation into the emerging intersection of cancer biology and cancer immunology. Divided into four sections, the volumes first three parts focus on cytokines in the genesis of cancer, including the role of chronic inflammation and the molecular mechanisms used by specific cytokines. Castlemans disease, multiple myeloma, cytokines in tumor stroma, receptor expression, and tumor necrosis factor in muscle wasting are all covered. The final section describes the notable progress both in animal models and humans in demonstrating the use of cytokine or anticytokine therapies for the prevention and treatment of cancer. IL-2, IL-12, type I interferons, novel strategies for targeting cytokine administration, cancer vaccines, and anticytokine therapy are included. Cytokines in the Genesis and Treatment of Cancer brings together an impressive array of internationally distinguished investigators who are devoted to the study of cytokines and cancer. Together, they produce an insightful, comprehensive discussion of cytokines and cancer that will serve as the perfect reference for all those working in the field.
Introduction
1. Overview and Introduction to Cancer and Inflammation
Michael A. Caligiuri and Michael T. Lotze
Part I. Cytokines in the Genesis of Cancer
Infectious Agents, Cytokines and Cancer
2. Helicobacter Pylori
Richard M. Peek, Jr.
3. HTLV-1
Michael Lairmore and Lee Ratner
4. Herpes Viruses
Frank J. Jenkins and Heather R. Hensler
Cytokines and Carcinogenesis
5. TNF
Mark DeWitte, David J. Shealy, Marian Nakada, and G. Mark Anderson
6. TGF-
Alyssa R. Bonine, Brian K. Law and Harold L. Moses
7. Interleukin 1 (IL-1) Family of Cytokines
Michael T. Lotze
8. IL-4/13
Koji Kawakami and Raj Puri
9. IL-6 and Castleman's disease
Norihiro Nishimoto
10. Interleukin 10 (IL-10) Family of Cytokines
Shin-ichiro Fujii and Michael Lotze
11. Cytokines in Multiple Myeloma: Therapeutic Implications
Dharminder Chauhan, Teru Hideshima and Kenneth Anderson
12. Murine Cytokine Models and the Genesis of Cancer
Todd A. Fehniger, Megan A. Cooper, Michael A. Caligiuri
13. Experimental Models of Cytokines and Cancer Prevention
Mark J. Smyth, Erika Cretney, Shayna E.A. Street and Yoshihiro Hayakawa
Cytokines and Tumor Stroma/Metastasis
14. Cytokines in the Tumor Stroma
Michael C. Ostrowski
15. Cytokines and Angiogenesis in Tumors
Sharmila Roy-Chowdhury and Charles K. Brown
16. Chemokines and Receptor Expression in Tumor Progression
Paola Allavena, Federica Marchesi and Alberto Mantovani
17. The Biology of Cancer Cachexia: Role of TNF±
Denis Guttridge
Part II: Cytokines in The Treatment Of Cancer
18. IL-2
Kim Margolin and Joe Clark
19. IL-12
Timothy E. Bael and Jared Gollob
20. The Type I Interferon Family
Stergios J. Moschos, Gregory B. Lesinski, William E. Carson, III, and John M. Kirkwood
21. Combination Cytokine Therapy
Seth Cohen and Howard Kaufman
22. Novel Strategies for Targeting Cytokine Administration
Paul M. Sondel, Jackie Hank, Mark Albertini and Stephen D. Gilles
23. Cytokines and Cancer Vaccines
Hideho Okada and Michael T. Lotze
24. Anti-cytokine Therapy
Miguel A. Villalona-Calero
25. Cytokines in the Supportive Care of Cancer
John A. Glaspy