Zweigstelle	Standorte	Status	Vorbestellungen	Frist	Barcode	Lageplan	Ausleihhinweis
Zweigstelle: Hauptstelle	Standorte: Serie	Status: Verfügbar	Vorbestellungen: 0	Frist:	Barcode: 00193160	Lagepläne: Lageplan	Ausleihhinweis:
Zweigstelle: Hauptstelle	Standorte: NA-10 26	Status: Verfügbar	Vorbestellungen: 0	Frist:	Barcode: 00192430	Lagepläne: Lageplan	Ausleihhinweis:
Zweigstelle: Hauptstelle	Standorte: NA-10 26 (2.Ex.)	Status: Verfügbar	Vorbestellungen: 0	Frist:	Barcode: 00192449	Lagepläne: Lageplan	Ausleihhinweis:

Epothilones have received unusual attention over the past ten years. They are novel antitumor drugs which very much like their predecessor paclitaxel (Taxol) act via microtubule stabilization. In comparison to paclitaxel and a number of alternative drugs with a similar mode of bioaction (e.g. laulimalide, eleutherobin, peluroside, discodermolide) the epothilones have significant advantages, above all very high activity in the nanomolar range and low susceptibility towards multidrug resistance. Epothilone B and several derivatives thereof are in phase I-III clinical trials; one of them (ixabepilone, BMS) is already on the market, others are supposed to appear on the market in the near future. All naturally occurring epothilones have been isolated from Sorangium cellulosum; their antitumor action is traced back to the stabilization of microtubules. In consequence, the formation of the mitototic spindle is prohibited and the cell undergoes apoptosis.