Within the last fifteen years, scientists have discovered that most groups of bacteria use a rich chemical lexicon to send and receive signals from other bacteria. Bacteria use these signals to coordinate a wide range of activities, including bioluminescence, sporulation, biofilm formation, horizontal DNA transfer, population density estimates, and pathogenesis. Understanding this communication will be crucial for future research in bacterial physiology, ecology, and bacterial disease. It may also be useful in intervening in bacterial processes, both harmful and beneficial.
This new volume of thirty chapters brings together the latest findings on chemical communication among bacteria and points towards potential areas for future research. Organized into four sections, this volume addresses: cell-cell signaling during development and DNA exchange; signaling in relationship to humans, animals, and plants; production and detection of chemical signals; and eukaryotic quorum sensing. Important new discoveries addressed include the structures of three bacterial signal synthases, signal receptors, mechanisms of signal transduction, pathways, and the expression of target genes.
Leading researchers in various aspects of bacterial signaling have contributed to this volume and provide a comprehensive overview of signal synthesis, detection, and its impacts on bacterial behavior. This indispensable book will be necessary reading for any microbiologist looking for a wide-ranging reference book on cell-cell signaling.
Key Features
* Gives authoritative and comprehensive explanations of chemical signaling and detection
* Summarizes in one volume the significant progress in understanding bacterial signaling
* Written by world leaders in the field
* Provides an understanding of signaling that may lead to new strategies in curing and prevention of bacterial diseases
* Provides a unique and comprehensive reference for microbiologists, physiologists, ecologists, microbial engineers, and clinicians
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Suggests new directions for future research
Table of Contents
I. Cell-Cell Signaling during Development and DNA Exchange
1. Intercompartmental Signal Transduction during Sporulation in Bacillus subtilis, David Z. Rudner and Thierry Doan
2. Extracellular Peptide Signaling and Quorum Responses in Development, Self-Recognition, and Horizontal Gene Transfer in Bacillus subtilis, Jennifer M. Auchtung and Alan D. Grossman
3. New Insights into Pheromone Control and Response in Enterococcus faecalis pCF10, Heather A. H. Haemig and Gary M. Dunny
4. C-Signal Control of Aggregation and Sporulation, Dale Kaiser
5. The Dif Chemosensory System Is Required for S Motility, Biofilm Formation, Chemotaxis, and Development in Myxococcus xanthus, Lawrence J. Shimkets
6. Heterocyst Development and Pattern Formation, M. Ramona Aldea, Krithika Kumar, and James W. Golden
7. Diverse Cell-Cell Signaling Molecules Control Formation of Aerial Hyphae and Secondary Metabolism in Streptomycetes, Joanne M. Willey and Justin R. Nodwell
8. Metabolites as Intercellular Signals for Regulation of Community-Level Traits, Russell D. Monds and George A. O’Toole
II. Cell-Cell Signaling in Mutualistic and Pathogenic Associations with Humans, Animals, and Plants
9. LuxR-Type Proteins in Pseudomonas aeruginosa Quorum Sensing: Distinct Mechanisms with Global Implications, Martin Schuster and E. P. Greenberg
10. Quorum Sensing in Vibrio cholerae Pathogenesis, Fiona R. Stirling, Zhi Liu, and Jun Zhu
11. Signal Integration and Virulence Gene Regulation in Staphylococcus aureus, Edward Geisinger and Richard P. Novick
12. Quorum Sensing in the Soft-Rot Erwinias, Sarah J. Coulthurst, Rita E. Monson, and George P. C. Salmond
13. Role of Quorum-Sensing Regulation in Pathogenesis of Pantoea stewartii subsp. stewartii, Susanne B. von Bodman, Aurelien L. Carlier, and Ann M. Stevens
14. Cell-to-Cell Communication in Rhizobia: Quorum Sensing and Plant Signaling, J. Allan Downie and Juan E. González
15. Quorum Signaling and Symbiosis in the Marine Luminous Bacterium Vibrio fischeri, E. V. Stabb, A. Schaefer, J. L. Bose, and E. G. Ruby
16. Acylated Homoserine Lactone Signaling in Marine Bacterial Systems, Elisha M. Cicirelli, Holly Williamson, Karen Tait, and Clay Fuqua
III. Production, Detection, and Quenching of Chemical Signals
17. Acyl-Homoserine Lactone Biosynthesis: Structure and Mechanism, Mair E. A. Churchill and Jake P. Herman
18. Cell-Cell Signaling within Crown Gall Tumors, Stephen C. Winans
19. A New Look at Secondary Metabolites, Michael G. Surette and Julian Davies
20. Signal Integration in the Vibrio harveyi and Vibrio cholerae Quorum-Sensing Circuits, Brian Hammer and Bonnie L. Bassler
21. Signal Trafficking with Bacterial Outer Membrane Vesicles, Lauren Mashburn-Warren and Marvin Whiteley
22. Cooperative Regulation of Competence Development in Streptococcus pneumoniae: Cell-to-Cell Signaling via a Peptide Pheromone and an Alternative Sigma Factor, Marco R. Oggioni and Donald A. Morrison
23. The A Factor Regulatory Cascade That Triggers Secondary Metabolism and Morphological Differentiation in Streptomyces, Sueharu Horinouchi
24. Quorum Quenching: Impact and Mechanisms, Lian-Hui Wang, Yi-Hu Dong, and Lian-Hui Zhang
25. Quorum-Sensing Inhibition, Staffan Kjelleberg, Diane McDougald, Thomas Bovbjerg Rasmussen, and Michael Givskov
IV. Eukaryotic Quorum Sensing and Interactions with Quorum-Sensing Bacteria
26. Interdomain Cross Talk, Carla Cugini, Roberto Kolter, and Deborah A. Hogan
27. Intercellular Signaling by Rhomboids in Eukaryotes and Prokaryotes, Matthew Freeman and Philip Rather
28. Quorum Sensing in Fungi, Claire C. Tseng and Gerald R. Fink
29. Quorum Sensing in Rotifers, Julia Kubanek and Terry W. Snell
30. “Quorum Sensing” in Honeybees: Pheromone Regulation of Division of Labor, Yves Le Conte, Zachary Huang, and Gene E. Robinson