Kurzbeschreibung
This work provides an overview of microbial proteomics with the aim of highlighting practical deliverables that can be applied to work in eukaryotic proteomes. It shows how accomplishments in this field have contributed to our understanding of genomic and cellular function, as well as modes of therapeutic action, drug toxicity and biomolecular interactions. Sections look at proteomics as applied to research in microbial physiology, model organism studies, microbes in agriculture, industry, and medicine, vaccinology, protein-protein networks, and mathematical modeling.
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PREFACE.
ACKNOWLEDGMENTS.
CONTRIBUTORS.
PART I: GENERAL PROTEOMICS OF MICROORGANISMS/MODEL ORGANISMS.
1. Holistic Biology of Microorganisms: Genomics, Transcriptomics, and Proteomics (Valerie Wasinger).
2. Strategies for Measuring Dynamics: The Temporal Component of Proteomics (Robert J. Beynon and Julie M. Pratt).
3. Quest for Complete Proteome Coverage (C. David O'Connor, Ian N. Clarke, and Paul Skipp).
4. Proteome of Mycoplasma pneumoniae (Richard Herrmann and Thomas Ruppert).
5. Proteomics of Archaea (Ricardo Cavicchioli, Amber Goodchild, and Mark Raftery).
PART II: PROTEOMICS AND CELL PHYSIOLOGY.
6. Elucidation of Mechanisms of Acid Stress in Listeria monocytogenes by Proteomic Analysis (Luu Phan-Thanh and Lothar Jänsch).
7. Oxidation of Bacterial Proteome in Response to Starvation (Thomas Nyström).
8. Tale of Two Metal Reducers: Comparative Proteome Analysis of Geobacter sulferreducens PCA and Shewanella oneidensis MR-1 (Carol S. Giometti).
9. AMT Tag Approach to Proteomic Characterization of Deinococcus radiodurans and Shewanella oneidensis (Mary S. Lipton, Margaret F. Romine, Matthew E. Monroe, Dwayne A. Elias, Ljiljana Pasa-Tolic, Gordon A. Anderson, David J. Anderson, Jim Fredrickson, Kim K. Hixson, Christophe Masselon, Heather Mottaz, Nikola Tolic, and Richard D. Smith).
PART III: PHYSIOLOGICAL PROTEOMICS OF INDUSTRIAL BACTERIA.
10. Proteomics of Corynebacterium glutamicum: Essential Industrial Bacterium (Andreas Burkovski).
11. Proteomics of Lactococcus lactis: Phenotypes for a Domestic Bacterium (Mogens Kilstrup).
12. Proteomic Survey through Secretome of Bacillus subtilis (Haike Antelmann, Jan Maarten van Dijl, Sierd Bron, and Michael Hecker).
PART IV: PROTEOMICS OF PATHOGENIC MICROORGANISMS.
13. Analyzing Bacterial Pathogenesis at Level of Proteome (Phillip Cash).
14. Unraveling Edwardsiella tarda Pathogenesis Using the Proteomics Approach (P. S. Srinivasa Rao, Yuen Peng Tan, Jun Zheng, and Ka Yin Leung).
15. Structural Proteomics and Computational Analysis of a Deadly Pathogen: Combating Mycobacterium tuberculosis from Multiple Fronts (Michael Strong and Celia W. Goulding).
16. Proteomic Studies of Plant-Pathogenic Oomycetes and Fungi (Catherine R. Bruce, Pieter van West, and Laura J. Grenville-Briggs).
17. Candida albicans Biology and Pathogenicity: Insights from Proteomics (Aida Pitarch, Ce?sar Nombela, and Concha Gil).
18. Contributions of Proteomics to Diagnosis, Treatment, and Prevention of Candidiasis (Aida Pitarch, Ce?sar Nombela, and Concha Gil).
19. Identification of Protein Candidates for Developing Bacterial Ghost Vaccines against Brucella (Vito G. Delvecchio, Tim Alefantis, Rodolfo A. Ugalde, Diego Comerci, Maria Ines Marchesini, Akbar Khan, Werner Lubitz, and Cesar V. Mujer).
20. Genomics and Proteomics in Reverse Vaccines (Guido Grandi).
PART V: PROTEOME DATABASES, BIOINFORMATICS, AND BIOCHEMICAL MODELING.
21. Databases and Resources for in silico Proteome Analysis (Manuela Pruess, Paul Kersey, Tamara Kulikova, and Rolf Apweiler).
22. Interspecies and Intraspecies Comparison of Microbial Proteins: Learning about Gene Ancestry, Protein Function, and Species Life Style (Bernard Labedan and Olivier Lespinet).
23. Cellular Kinetic Modeling of the Microbial Metabolism (Igor I. Goryanin, Galina V. Lebedeva, Ekaterina A. Mogilevskaya, Eugeniy A. Metelkin, and Oleg V. Demin).
INDEX.