Table of contents
Foreword: Sir Edwin Southern
Introduction: Krishnarao Appasani
Section 1: BioArray Technology Platforms
Chapter 1: The Investigation of Tumour Metastasis using cDNA Microarrays
David Murray, Francesco Gorreta, Geraldine Grant, Vikas Chandhoke and Susan McDonnell
Chapter 2: From tissue samples to tumor markers
Dirce Maria Carraro, Helena Paula Brentani, Fernando Augusto Soares,
Luiz Fernando Lima Reis and Ricardo Renzo Brentani
Charter 3: Experimental design for assessment of gene expression changes using microarrays. Answers are easy, is asking the right question difficult?
Marcia V. Fournier, Paulo da Costa Carvalho, David D. Magee and Maria da Gloria Costa Carvalho
Chapter 4: From Microarrays to Gene Networks
Hasan H. Otu and Towia A. Liberman
Section 2: Biomarkers and Clinical Genomics
Charter 5: Reduction in Sample Heterogeneity Leads to Increased Microarray Sensitivity
Williams, Amanda J.; Hagan, Kevin W.; Culp, Steve G.; Medd, Amy; Mrzljak, Ladislav; Defay, Tom R., and Mallamaci, Michael A.
Chapter 6: Genomics to identify biomarkers of normal brain aging
Loubna Erraji-Benchekroun, Victoria Arango, John J. Mann, and Mark D. Underwood
Chapter 7: Gene expression profiling for biomarker discovery
Kazuhiko Uchida
Chapter 8: Array-based Comparative Genomic Hybdidization: applications in cancer and tuberculosis
Murali D. Bashyam and Seyed E. Hasnain
Chapter 9: The regional specialization of endothelial cell as revealed by genomic analysis
Jen-Tsan Ashley Chi, Zhen Wang and Anil Potti
Section 3: Biomarker Identification Using Clinical proteomics and Glycomics
Chapter 10: Identification of target antigens in CNS inflammation by protein array technique
Sabine Cepok, Bernhard Hemmer, Konrad Büssow
Chapter 11: Differential Protein Expressio, Protein profiles of Human Gliomas and Clinical Implications
.Ravi Sirdeshmukh, Vani Santosh and Anusha Srikanth
Chapter 12: Antibody-Based Microarrays: From Focussed Assays to Proteome-Scale Analysis
Christer Wingren and Carl AK Borrebaeck
Chapter 13: GlycoProfiling by DNA-Sequencer Aided-Fluorophore Assisted Carbohydrate Electrophoresis: new opportunities in diagnosing and following disease
Wouter Laroy and Roland Contreras
Chapter 14: A high-throughput biochip platform for constructing carbohydrate microarrays
Denong Wang, Dhaval Shah , Ruobing Wang, Shaoyi Liu, Aili Wang, Xiaoyuan Xu,
Brian J. Trummer, Chao Deng and Rong Chen
Section 4: Emerging Technologies in Diagnostics
Chapter 15: Microarrays and blood diagnostics
Juraj Petrik and Janine Scott Robb
Chapter 16: Lab-on-a-chip devices for cellular arrays based on dielectrophoresis
ROBERTO GAMBARI, MONICA BORGATTI, ENRICA FABBRI, RICCARDO GAVIOLI, CINZIA FORTINI, CLAUDIO NASTRUZZI, LUIGI ALTOMARE, MELANIE ABONNEC, NICOL? MANARESI, GIANNI MEDORO, ALDO ROMANI, MARCO TARTAGNI AND ROBERTO GUERRIERI
Chapter 17: Genetic Disorders and Approaches to their Prevention
G. R. Chandak and J. Hemavathi
About this book
This book provides an integrated and comprehensive collection of timely articles on the use of bioarray techniques in the fields of biotechnology and molecular medicine. The entire volume is broken into four sections that create one well-integrated work Bioarray Technology Platforms, Biomarkers and Clinical Genomics, Biomarker Identification Using Clinical Proteomics and Glycomics, and Emerging Technologies in Diagnostics. Particular emphasis is placed on DNA, protein, and carbohydrate biochips. The volume also looks extensively at oligonucleotides, cDNA, proteins, antibodies, and carbohydrate arrays.
This book serves as an indispensable reference for graduate students, post-docs, and professors as well as an explanatory analysis for executives and scientists in biotechnology and pharmaceutical companies.