Volume 1
Kurzbeschreibung
Metal Ions in Life Sciences, links coordination chemistry and biochemistry in their widest sense and thus increases our understanding of the relationship between the chemistry of metals and life processes. This exciting series reflects the interdisciplinary nature of biological chemistry and coordinates the efforts of scientists in fields like biochemistry, inorganic and coordination chemistry, molecular and structural biology, enzymology, environmental chemistry, physiology, toxicology, biophysics, pharmacy, and medicine. Volume 45: Neurodegenerative Diseases and Metal Ions focuses on the devastating effects metal ions can have on proteins and related compounds.
Aus dem Inhalt
1 The Role of Metal Ions in Neurology
2 Protein Folding, Misfolding, and Disease
3 Metal Ion Binding Properties of Proteins Related to Neurodegeneration
4 Metallic Prions: Mining the Core of Transmissible Spongiform Encephalopathies
5 The Role of Metal Ions in the Amyloid Precursor Protein and in Alzheimer's Disease
6 The Role of Iron in the Pathogenesis of Parkinson's Disease
7 In Vivo Assessment of Iron in Huntington's Disease and Other Age-Related Neurodegenerative Brain Diseases
8 Copper-Zinc Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis
9 The Malfunctioning of Copper Transport in Wilson and Menkes Diseases
10 Iron and Its Role in Neurodegenerative Diseases
11 The Chemical Interplay between Catecholamines and Metal Ions in Neurological Diseases
12 Zinc Metalloneurochemistry: Physiology, Pathology, and Probes
13 The Role of Aluminum in Neurotoxic and Neurodegenerative Processes
14 Neurotoxicity of Cadmium, Lead, and Mercury
15 Neurodegenerative Diseases and Metal Ions. A Concluding Overview
Langtext
Volume 2 focuses on the vibrant research area concerning nickel as well as its complexes and their role in Nature. With more than 2800 references and over 130 illustrations, it is an essential resource for scientists working in the wide range from inorganic biochemistry all the way through to medicine.
In 17 stimulating chapters, written by 47 internationally recognized experts, Nickel and Its Surprising Impact in Nature highlights critically the biogeochemistry of nickel, its role in the environment, in plants and cyanobacteria, as well as for the gastric pathogen Helicobacter pylori, for gene expression and carcinogenesis. In addition, it covers the complex-forming properties of nickel with amino acids, peptides, phosphates, nucleotides, and nucleic acids. The volume also provides sophisticated insights into the recent progress made in understanding the role of nickel in enzymes such as ureases, hydrogenases, superoxide dismutases, acireductone dioxygenases, acetyl-coenzyme A synthases, carbon monoxide dehydrogenases, methyl-coenzyme M reductases ... and it reveals the chaperones of nickel metabolism.
Aus dem Inhalt
1 BIOGEOCHEMISTRY OF NICKEL AND ITS RELEASE INTO THE ENVIRONMENT (Tiina M. Nieminen, Liisa Ukonmaanaho, Nicole Rausch, and William Shotyk).
2 NICKEL IN THE ENVIRONMENT AND ITS ROLE IN THE METABOLISM OF PLANTS AND CYANOBACTERIA (Hendrik Küpper and Peter M. H. Kroneck).
3 NICKEL ION COMPLEXES OF AMINO ACIDS AND PEPTIDES (Teresa Kowalik-Jankowska, Henryk Kozlowski, Etelka Farkas, and Imre Sóvágó).
4 COMPLEX FORMATION OF NICKEL(II) AND RELATED METAL IONS WITH SUGAR RESIDUES, NUCLEOBASES, PHOSPHATES, NUCLEOTIDES, AND NUCLEIC ACIDS (Roland K. O. Sigel and Helmut Sigel).
5 SYNTHETIC MODELS FOR THE ACTIVE SITES OF NICKEL-CONTAINING ENZYMES (Jarl Ivar van der Vlugt and Franc Meyer).
6 UREASE: RECENT INSIGHTS ON THE ROLE OF NICKEL (Stefano Ciurli).
7 NICKEL IRON HYDROGENASES (Wolfgang Lubitz, Maurice van Gastel, and Wolfgang Gärtner).
8 METHYL-COENZYME M REDUCTASE AND ITS NICKEL CORPHIN COENZYME F430 IN METHANOGENIC ARCHAEA (Bernhard Jaun and Rudolf K. Thauer).
9 ACETYL-COENZYME A SYNTHASES AND NICKEL-CONTAINING CARBON MONOXIDE DEHYDROGENASES (Paul A. Lindahl and David E. Graham).
10 NICKEL SUPEROXIDE DISMUTASE (Peter A. Bryngelson and Michael J. Maroney).
11 BIOCHEMISTRY OF THE NICKEL-DEPENDENT GLYOXALASE I ENZYMES (Nicole Sukdeo, Elisabeth Daub, and John F. Honek).
12 NICKEL IN ACIREDUCTONE DIOXYGENASE (Thomas C. Pochapsky, Tingting Ju, Marina Dang, Rachel Beaulieu, Gina M. Pagani, and Bo OuYang).
13 THE NICKEL-REGULATED PEPTIDYL PROLYL CIS/TRANS ISOMERASE SlyD (Frank Erdmann and Gunter Fischer).
14 CHAPERONES OF NICKEL METABOLISM (Soledad Quiroz, Jong K. Kim, Scott B. Mulrooney, and Robert P. Hausinger).
15 THE ROLE OF NICKEL IN ENVIRONMENTAL ADAPTATION OF THE GASTRIC PATHOGEN HELICOBACTER PYLORI (Florian D. Ernst, Arnoud H. M. van Vliet, Manfred Kist, Johannes G. Kusters, and Stefan Bereswill).
16 NICKEL-DEPENDENT GENE EXPRESSION (Konstantin Salnikow and Kazimierz S. Kasprzak).
17 NICKEL TOXICITY AND CARCINOGENESIS (Kazimierz S. Kasprzak and Konstantin Salnikow).
SUBJECT INDEX.
Kurzbeschreibung
This text offers a systematic account of new results in Cytochrome P450 research. The coverage ranges across a wide span of chapters, starting with overviews and the presentation of specific systems, and ending with chapters on carbon-carbon bond cleavage by P450 sytems, drug metabolism as catalyzed by P450 systems, decomposition of xenobiotics by P450 enzymes and design and engineering of new P450 systems.
Aus dem Inhalt
HISTORICAL DEVELOPMENT AND PERSPECTIVES OF THE SERIES.
PREFACE TO VOLUME 3.
CONTRIBUTORS TO VOLUME 3.
TITLES OF VOLUMES 1-44 IN THE METAL IONS IN BIOLOGICAL SYSTEMS SERIES.
CONTENTS OF VOLUMES IN THE METAL IONS IN LIFE SCIENCES SERIES.
1 DIVERSITIES AND SIMILARITIES IN P450 SYSTEMS: AN INTRODUCTION (Mary A. Schuler and Stephen G. Sligar).
2 STRUCTURAL AND FUNCTIONAL MIMICS OF CYTOCHROMES P450 (Wolf-D. Woggon).
3 STRUCTURES OF P450 PROTEINS AND THEIR MOLECULAR PHYLOGENY (Thomas L. Poulos and Yergalem T. Meharenna).
4 AQUATIC P450 SPECIES (Mark J. Snyder).
5 THE ELECTROCHEMISTRY OF CYTOCHROME P450 (Alan M. Bond, Barry D. Fleming, and Lisandra L. Martin).
6 P450 ELECTRON TRANSFER REACTIONS (Andrew K. Udit, Stephen M. Contakes, and Harry B. Gray).
7 LEAKAGE IN CYTOCHROME P450 REACTIONS IN RELATION TO PROTEIN STRUCTURAL PROPERTIES (Christiane Jung).
8 CYTOCHROMES P450 - STRUCTURAL BASIS FOR BINDING AND CATALYSIS (Konstanze von König and Ilme Schlichting).
9 BEYOND HEME-THIOLATE INTERACTIONS: ROLES OF THE SECONDARY COORDINATION SPHERE IN CYTOCHROME P450 SYSTEMS (Yi Lu and Thomas D. Pfister).
10 INTERACTIONS OF CYTOCHROME P450 WITH NITRIC OXIDE AND RELATED LIGANDS (Andrew W. Munro, Kirsty J. McLean, and Hazel M. Girvan).
11 CYTOCHROME P450-CATALYZED HYDROXYLATIONS AND EPOXIDATIONS (Roshan Perera, Shengxi Jin, Masanori Sono, and John H. Dawson).
12 CYTOCHROME P450 AND STEROID HORMONE BIOSYNTHESIS (Rita Bernhardt and Michael R. Waterman).
13 CARBON-CARBON BOND CLEAVAGE BY P450 SYSTEMS (James J. De Voss and Max J. Cryle).
14 DESIGN AND ENGINEERING OF CYTOCHROME P450 SYSTEMS (Stephen G. Bell, Nicola Hoskins, Christopher J. C. Whitehouse, and Luet L. Wong).
15 CHEMICAL DEFENSE AND EXPLOITATION. BIOTRANSFORMATION OF XENOBIOTICS BY CYTOCHROME P450 ENZYMES (Elizabeth M. J. Gillam and Dominic J. B. Hunter).
16 DRUG METABOLISM AS CATALYZED BY HUMAN CYTOCHROME P450 SYSTEMS (F. Peter Guengerich).
17 CYTOCHROME P450 ENZYMES: OBSERVATIONS FROM THE CLINIC (Peggy L. Carver).
SUBJECT INDEX.