This Glycobiology book is truly unique. Produced to commemorate the 80th birthday of Nathan Sharon, Glycobiology is an essential reference tool for anyone working in the field.
Most research review volumes are narrowly focused. This book is different. It is a state-of-the-art fully comprehensive review volume covering a deliberately wide spectrum of work in this important field. With 28 chapters, covering over 350 pages, this title describes the latest research findings - from chemistry to biology and from pure science to industrial and medical applications.
The book is written by world-class researchers and brings the reader fully up-to-date with the latest advances and forward thinking. All the major areas of glycobiology are covered including the synthesis of carbohydrates and glycoconjugates, their structural and functional analysis, carbohydrate binding proteins, carbohydrate modifying enzymes, and the applications of glycobiology research in medicine and industry.
All active researchers in the glycosciences will value access to this important research compendium whether it be in the local library or in the lab.
Contents
SECTION 1. Introduction
1. Half a century at the carbohydrate-protein interface (Clare Sansom)
2. Glycobiology - discovery, diagnostics and drugs (Raymond Dwek)
SECTION 2. Synthesis of Carbohydrate and Glycoconjugates
3. Sugar-lectin interactions: glycotargeting with synthetic glycoconjugates (Michel Monsigny et al .)
4. Recent developments in the synthesis and application of sialylmimetics (Hansjorg Streicher and Heike Busse)
SECTION 3. Analysis and Structure
5. Structure and function of the chondroitin/dermatan sulfates (Robert Lauder)
6. Revealing the hidden dimensions of glycosaminoglycans in solution and protein complexes with saccharide libraries, FTIR, and SRCD (David Fernig et al .)
7. S tructural determination of N-linked glycans by matrix-assisted laser desorption/ionization and electrospray ionization mass spectrometry (David Harvey)
8. Integrated approach to glycan structure-function relationships (Ram Sasisekharan)
SECTION 4. Cell Biology of Carbohydrates and Glycoproteins
9. Some observations on the biology of cell surface heparan sulfate proteoglycans (John Gallagher)
10. Galectins: effective modulators of cytoskeletal organization and cellular growth - focus on galectin-8 as a model system (Yehiel Zick)
11. Intracellular lectin involvement in glycoprotein maturation and quality control in the secretory pathway (Gerardo Lederkremer)
SECTION 5. Carbohydrate-Binding Proteins
12. The diversity of sialic acids and their interplay with lectins (Roland Schauer)
13. Structure and carbohydrate specificity of beta -p rism I fold lectins (M. Vijayan, V. Surolia and K. Sekar)
14. Protein-glycan interactions in immunoregulation: galectins as tuners of the inflammatory response (Gabriel Rabinovich)
15. Recognition of bacterial glycoepitopes by pulmonary C-type lectins as an arm of lung innate immunity (Itzhak Ofek)
16. Selectin and integrin recognition of ligands under shear flow: affinity and beyond (Ronen Alon, Revital Shamri and Sara Feigelson)
SECTION 6. Carbohydrate-Modifying Enzymes
17. Complex carbohydrate-modifying enzymes (Karen J. Loft andSpencer Williams)
18. Glycosyltransferases specific for the synthesis of mucin-type O-glycans (Inka Brockhausen)
19. Glycosylation in development (Shaolin Shi and Pamela Stanley)
SECTION 7. Glycobiology and Medicine
20. Glycobiology of mucins in the human gastrointestinal tract (Anthony P. Corfield)
21. Mucosal glycoconjugates in inflammatory bowel disease and colon cancer (Barry Campbell, Lu-Gang Yu and Jonathan Rhodes)
22. Selectin-mediated metastasis of tumor cells: Alteration of carbohydrate-mediated cell-cell interactions in cancers induced by epigenetic silencing of glycogenes (Reiji Kannagi et al .)
23. Glycosphingolipids in health and disease (Swetlana A. Boldin-Adamsky and Tony Futerman)
24. Pathogen-host interactions in Entamoeba histolytica (David Mirelman and William A. Petri, Jr)
SECTION 8. Industrial Glycobiology
25. The development of iminosugars as drugs (Bryan Winchester)
26. Carbohydrate biosensors (Raz Jelinek and Sofiya Kolusheva)
27. Glycoanalysis on a lectin array: applications to the development of biopharmaceuticals and life science research (Rakefet Rosenfeld et al.)
28. Lectin chips and CarboDeep '99: a rapid carbohydrate fingerprinting technology and its application for the food scientists (Gabriel Faiman andOfer Markman)
Afterword by Nathan Sharon