The DNA tumor viruses are central to many branches of molecular and cellular biology. This very diverse group of viruses attack common cellular pathways, which makes them powerful tools for understanding how multiple complex pathways are integrated. Additionally, the unique mechanisms employed by each viral system to alter cellular functions serve as powerful molecular probes for the identification of new targets and pathways. The scientific impact of the DNA tumor viruses extends far beyond their etiologic role in human cancers, or their contributions to our basic understanding of the cellular pathways that drive tumorigenesis. Currently, research on these viruses lies at the interface of cancer and the innate and adaptive immune response, investigating how infectious agents influence, evade, and utilize systems that regulate these processes. Thus, DNA tumor viruses serve as models for the systems biology of host-pathogen interactions.
Table of contents
INTRODUCTION
James Pipas and Blossom Damania
CHAPTER 1
Polyomavirus Life Cycle
Ellen Fanning, Xiaorong Zhao, and Xiaohua Jiang
CHAPTER 2
Transformation by Polyomaviruses
Dweepanita Das and Michael J. Imperiale
CHAPTER 3
Polyomaviruses and Disease
Jaime M. Kean and Robert L. Garcea
CHAPTER 4
The Life Cycle of Human Papillomaviruses
Cary A. Moody and Laimonis A. Laimins
CHAPTER 5
Papillomavirus Transformation
Kimberly Johung and Daniel DiMaio
CHAPTER 6
Papillomaviruses: Biology, Diversity and Pathogenesis.
Hans Uli Bernard
CHAPTER 7
Adenovirus Transformation
Patrick Hearing
CHAPTER 8
Overview of the Large DNA Tumor Viruses
Subhash C. Verma, Qiliang Cai, Bharat G. Bajaj and Erle S. Robertson
CHAPTER 9
Epidemiology of EBV Infection
Rosemary Rochford
CHAPTER 10
Epstein-Barr Virus Diseases
Joseph S. Pagano
CHAPTER 11
The EBV Viral Genome
Jeffrey Sample and Clare Sample
CHAPTER 12
Epstein Barr Virus Transforming Proteins: Biologic Properties and Contribution to Oncogenesis Nancy Raab-Traub
CHAPTER 13
The Epstein-Barr Virus Lytic Lifecycle
Sankar Swaminathan and Shannon Kenney
CHAPTER 14
Epstein-Barr Virus Latent Infection Nuclear Proteins; Genome maintenance and regulation of lymphocyte cell growth and survival
Eric Johannsen, Michael Calderwood, Myung-Soo Kang, Bo Zhao, Daniel Portal, and Elliott Kieff
CHAPTER 15
Epstein-Barr Virus Entry
Richard Longnecker, Lindsey Hutt-Fletcher, Ted Jardetzky
CHAPTER 16
Epstein-Barr Virus Immunotherapy
Leslie E. Huye and Cliona M. Rooney
CHAPTER 17
Kaposi’s Sarcoma-associated Herpesvirus Epidemiology and Subtype Evolution
Gary S. Hayward and Denise Whitby
CHAPTER 18
Introduction to diseases associated with Kaposi’s Sarcoma-associated Herpesvirus
Patrick S. Moore and Yuan Chang
CHAPTER 19
Organization and Expression of the Kaposi’s Sarcoma-associated Herpesvirus Genome
Yan Yuan and Rolf Renne
CHAPTER 20
Kaposi’s Sarcoma-associated Herpesvirus latent genes and their regulation
Dirk P. Dittmer
CHAPTER 21
Regulation of Expression, Mode of Action and Downstream Targets of ORF50 Protein in KSHV Lytic Cycle Activation.
Pey-Jium Chang, Jianjiang Ye, and George Miller.
CHAPTER 22
HHV-8/KSHV proteins involved in signaling and transformation
Silke Hartmann, Thomas F. Schulz, and John Nicholas
CHAPTER 23
Kaposi’s Sarcoma-associated Herpesvirus entry and infection of target cells
Bala Chandran and Neelam Sharma-Walia
CHAPTER 24
Kaposi’s Sarcoma-associated Herpesvirus Immune Evasion
Chengyu Liang, Hyera Le, Liguo Wu, Pinghui Feng, and Jae U. Jung
CHAPTER 25
Non-coding regulatory RNAs of the DNA Tumor viruses
Christopher S. Sullivan and Bryan R. Cullen
CHAPTER 26
AIDS and associated malignancies
William J. Harrington, Jr. and Charles Wood
CHAPTER 27
Primate Models for Gammaherpesvirus-associated Malignancies
Ilhem Messaoudi, Blossom Damania and Scott W. Wong
CHAPTER 28
Murine Gammaherpesvirus 68 Infection of Mice: a Small Animal Model for Characterizing Basic Aspects of Gamma-herpesvirus Pathogenesis
James Craig Forrest, Laurie T. Krug, and Samuel H. Speck