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Kurzbeschreibung

Coinciding with the first TB therapies to enter clinical trials in 60 years, in 3 volumes this is the most comprehensive account of the latest developments in clinical, therapeutic and basic research into the disease, presented by the most prolific researcher in the field.

 

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VOLUME 1: MOLECULAR BIOLOGY AND BIOCHEMISTRY

Tuberculosis - Molecular Genetics and Biochemistry: Introduction

Biochemistry of the Cell Wall

Glycolipids and Polyketides of M. tuberculosis

Physiology of M. tuberculosis

Nutrient Transport

Iron Uptake by M. tuberculosis

Protein Transport

PE and PPE Gene Family Members in M. tuberculosis

Virulence/Persistence Mechanisms of M. tuberculosis

Genomics

Transcriptomics and Transcriptional Regulation

Proteomics of M. tuberculosis

Structure

Molecular Mechanisms of Dormancy and Resuscitation

M. tuberculosis in the Phagosome

Molecular Mechanisms of Drug Resistance of M. tuberculosis

Experimental Genetics of M. tuberculosis

Molecular Evolution of Mycobacteria

 

VOLUME 2: IMMUNOLOGY AND CELL BIOLOGY

Introduction: Immunity to M. tuberculosis and BCG

Recognition Receptors and Phagocytosis for M. tuberculosis

Transcriptional Response of Macrophages and Dendritic Cells to M. tuberculosis

Dendritic Cells and Antigen Presentation

Killing Mechanisms of the Host Against M. tuberculosis

Manipulation of the Macrophage Response

Conventional T Cells and their Antigenic Repertoire

Unconventional T Cells

Cytokines in Tuberculosis

Antibodies in Tuberculosis

Pathology

Maintenance of Latent Infection with Correlates of Protective Immunity

Genetics of Resistance (mouse and man)

HIV/TB Interactions

Novel Vaccination Strategies Against Tuberculosis

Experimental Animal Models of Tuberculosis

 

VOLUME 3: CLINICS DIAGNOSTICS THERAPY AND EPIDEMIOLOGY

Clinics Diagnostics Therapy Epidemiology: Introduction

Global Epidemiology of Tuberculosis

Surveillance Studies and Interpretation

Molecular Epidemiology of M. tuberculosis

Diagnosis of M. tuberculosis: Clinical

Clinical Disease (with and without HIV)

Management of Tuberculosis Patients

Chemotherapy

New Drugs and Clinical Drug Trials

Latency

Drug Resistance in Clinical Context

Novel Drug Treatment Strategies - Co-infections

Modeling

BCG Vaccination