Zweigstelle	Standorte	Status	Vorbestellungen	Frist	Barcode	Lageplan	Ausleihhinweis
Zweigstelle: Hauptstelle	Standorte: ME-20 73	Status: Verfügbar	Vorbestellungen: 0	Frist:	Barcode: 00185930	Lagepläne: Lageplan	Ausleihhinweis:

Kurzbeschreibung

This book explores and discusses some of the most important topics in post-genomics life and biopharmaceutical sciences such as pharmacogenomics, chemical genomics, chemical biology, structural genomics, drug discovery, biophysics and bioengineering with various chapters contributed by experts in respective fields. As such, the book provides both graduate students and researchers related to or interested in pharmaceutical and medicinal chemistry and biotechnology with introduction and examples of many techniques presently used, as well as emerging ones that are important for the research of biopharmaceutical discovery in the post genomics era.

 

Aus dem Inhalt

FOREWORD.

 

INTRODUCTION.

 

CONTRIBUTORS.

 

PART I. COMPUTATIONAL AND STRUCTURAL APPROACHES IN DRUG DISCOVERY.

 

CHAPTER 1. MOLECULAR DOCKING AND STRUCTURE-BASED DESIGN.

 

CHAPTER 2. RECENT ADVANCES IN DRUG DISCOVERY RESEARCH USING STRUCTURE-BASED VIRTUAL SCREENING TECHNIQUES: EXAMPLES OF SUCCESS FOR DIVERSE PROTEIN TARGETS.

 

CHAPTER 3. VIRTUAL SCREENING IN DRUG DISCOVERY.

 

CHAPTER 4. COMPUTER-AIDED DRUG DESIGN.

 

CHAPTER 5. FOCUSED LIBRARY DESIGN BASED ON HIT AND TARGET STRUCTURES: METHOD AND APPLICATION IN DRUG DISCOVERY.

 

PART II. CHEMICAL AND SYNTHETIC APPROACHES IN DRUG DISCOVERY.

 

CHAPTER 6. BEYOND NATURAL PRODUCTS: SYNTHETIC ANALOGUES OF BRYOSTATIN 1.

 

CHAPTER 7. THE PROMISES AND PITFALLS OF SMALL-MOLECULE INHIBITION OF POLY(ADP-RIBOSE) GLYCOHYDROLASE (PARG).

 

CHAPTER 8. CYCLIC ADP-RIBOSE ANALOGUES WITH MINIMAL STRUCTURE: SYNTHESIS AND CALCIUM-RELEASE ACTIVITY.

 

CHAPTER 9. EVALUATION OF NEUROIMMUNOPHILIN LIGANDS.

 

CHAPTER 10. CHIRAL DRUGS AND THE ASSOCIATED ASYMMETRIC SYNTHESIS.

 

CHAPTER 11. ALPHA-HELIX MIMETICS IN DRUG DISCOVERY 281

 

CHAPTER 12. BASIC AND TRANSLATIONAL RESEARCH OF CHEMOKINE LIGANDS AND RECEPTORS AND DEVELOPMENT OF NOVEL THERAPEUTICS.

 

CHAPTER 13. RESEARCH PROGRESS IN PROTEIN POST-TRANSLATIONAL MODIFICATION.

 

CHAPTER 14. CONTROLLED RELEASE OFANTIBIOTICS ENCAPSULATED IN NANOPOROUS SOL-GEL MATERIALS WITH TUNABLE PORE PARAMETERS.

 

PART III. BIOLOGICAL APPROACHES AND TRANSLATIONAL RESEARCH IN DRUG DISCOVERY.

 

CHAPTER 15. RETINOIC ACID AND ARSENIC TRIOXIDE TREATMENT IN ACUTE PROMYELOCYTIC LEUKEMIA: A MODEL OF ONCOPROTEIN TARGETED THERAPY.

 

CHAPTER 16. 2-CHLORODEOXYADENOSINE.

 

CHAPTER 17. APOPTOSIS-BASED DRUG DISCOVERY FOR CANCER.

 

CHAPTER 18. MECHANISM-BASED DEVELOPMENT OF MEMANTINE AS A THERAPEUTIC AGENT IN TREATING ALZHEIMER'S DISEASE AND OTHER NEUROLOGIC DISORDERS: LOW-AFFINITY, UNCOMPETITIVE ANTAGONISM WITH FAST OFF-RATE.

 

CHAPTER 19. BRIDGING BENCH TO CLINIC: ROLES OFANIMAL MODELS FOR POST-GENOMICS DRUG DISCOVERY ON METABOLIC DISEASES.

 

CHAPTER 20. STEM CELL RESEARCH AND APPLICATIONS FOR HUMAN THERAPIES.

 

INDEX.