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Based on the award winning Wiley Encyclopedia of Chemical Biology, this book provides a general overview of the unique features of the small molecules referred to as "natural products", explores how this traditionally organic chemistry-based field was transformed by insights from genetics and biochemistry, and highlights some promising future directions. The book begins by introducing natural products from different origins, moves on to presenting and discussing biosynthesis of various classes of natural products, and then looks at natural products as models and the possibilities of using them in medicine.

TOC:

Preface vii

Contributors ix

 

PART I CHEMICAL DIVERSITY OF NATURAL PRODUCTS 1

 

1 Plant Natural Products 3

A. Leslie Gunatilaka

 

2 Marine Natural Products 31

Nobuhiro Fusetani

 

3 Microbial Natural Products 65

Sergio Sanchez, Silvia Guzma´n-Trampe, Mariana A´valos, Beatriz Ruiz, Romina Rodr´?guez-Sanoja, and Manuel Jim´enez-Estrada

 

PART II BIOSYNTHESIS OF NATURAL PRODUCTS 109

 

4 Nonribosomal Peptides 111

Georg Schoenafinger and Mohamed A. Marahiel

 

5 Plant Terpenoids 127

Christopher I. Keeling and J¨org Bohlmann

 

6 Polyketides in Fungi 143

Thomas J. Simpson and Russell J. Cox

 

7 Modular Polyketide Synthases 163

Tonia J. Buchholz, Jeffrey D. Kittendorf, and David H. Sherman

 

8 Polyketide Polyethers 189

Alison M. Hill

 

9 Alkaloids 209

Sarah E. O’Connor

 

10 Cofactors 239

Ilka Haase, Markus Fischer, Adelbert Bacher, Wolfgang Eisenreich, and Felix Rohdich

 

11 Antibiotics 269

Sergey B. Zotchev

 

PART III NATURAL PRODUCTS IN MEDICINE 287

 

12 Pharmaceuticals: Natural Products and Natural Product Models 289

Sheo B. Singh

 

13 Natural Products as Anticancer Agents 325

David G. I. Kingston and David J. Newman

 

14 Plant-Derived Natural Products Research in Drug Discovery 351

Kuo-Hsiung Lee, Hideji Itokawa, Toshiyuki Akiyama, and Susan L. Morris-Natschke

 

Index 389