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Zweigstelle: Hauptstelle	Standorte: BC-40 67	Status: Verfügbar	Vorbestellungen: 0	Frist:	Barcode: 00260991	Lagepläne: Lageplan	Ausleihhinweis:

Book Description:

This book gives biochemists, geneticists, and related investigators a comprehensive and up-to-date review and evaluation of telomerase research, a key subfield in understanding genetic function and diseases. Chapters cover the basic structure, mechanisms, and diversity of the essential and regulatory subunits of telomerase. Other topics discussed include telomerase biogenesis, transcriptional and post-translational regulation, off-telomere functions of telomerase, and the role of telomerase in cellular senescence, aging, and cancer. The text also reviews relevant information for retrotransposons, a class of mobile genetic elements serving as telomeres in selected organisms.

 

TOC:

 

Preface vii

 

Contributors ix

 

1 The Telomerase Complex: An Overview 1

Johanna Mancini and Chantal Autexier

 

2 Telomerase RNA: Structure, Function, and Molecular Mechanisms 23

Yehuda Tzfati and Julian J.-L. Chen

 

3 TERT Structure, Function, and Molecular Mechanisms 53

Emmanuel Skordalakes and Neal Lue

 

4 Telomerase Biogenesis: RNA Processing, Trafficking, and Protein Interactions 79

Tara Beattie and Pascal Chartrand

 

5 Transcriptional Regulation of Human Telomerase 105

Antonella Farsetti and Yu-Sheng Cong

 

6 Telomerase Regulation and Telomere-Length Homeostasis 135

Joachim Lingner and David Shore

 

7 Telomere Structure in Telomerase Regulation 157

Momchil D. Vodenicharov and Raymund J. Wellinger

 

8 Off-Telomere Functions of Telomerase 201

Kenkichi Masutomi and William C. Hahn

 

9 Murine Models of Dysfunctional Telomeres and Telomerase 213

Yie Liu and Lea Harrington

 

10 Cellular Senescence, Telomerase, and Cancer in Human Cells 243

Phillip G. Smiraldo, Jun Tang, Jerry W. Shay, and Woodring E. Wright

 

11 Telomerase, Retrotransposons, and Evolution 265

Irina R. Arkhipova