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This book is the eagerly awaited second edition of the best-selling Mitochondria, a book widely acknowledged as the first modern, truly comprehensive authored work on the important, scientifically fundamental topic of the cellular organelles known as mitochondria. As in that seminal first edition, the second edition tackles the biochemistry, genetics, and pathology of mitochondria in different organisms. The new edition provides thorough updates of all literature concerning this vital organelle, its functions, ongoing research surrounding it, and its importance vis-à-vis a broad range of issues in cellular and molecular biology. The book includes detailed descriptions of current and developing technologies around mitochondrial research and discovery, and highlights subjects that are growing, such as the use of proteomics.

 

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I. HISTORY.

 

References.

 

II. EVOLUTIONARY ORIGIN OF MITOCHONDRIA.

 

References.

 

III. STRUCTURE AND MORPHOLOGY. INTEGRATION INTO THE CELL.

 

3.1 Structure and Morphology.

 

3.2 Integration into the Cell.

 

3.3. The dynamics of mitochondrial morpholoy.

 

References.

 

IV. BIOGENESIS OF MITOCHONDRIA.

 

4.1 The Mitochondrial Genome.

 

4.2 Nuclear Genes encoding Mitochondrial Proteins.

 

Genome.

 

4.3 Replication and Maintenance of Mitochondrial DNA.

 

4.4 Transcription of Mitochondrial DNA - RNA Metabolism.

 

4.5 Translation of mitochondrial mRNAs.

 

4.6 Protein Import into Mitochondria.

 

4.7 Import of tRNA into Mitochondria.

 

4.8 Regulated Protein Degradation in Mitochondria.

 

References.

 

V. MITOCHONDRIAL ELECTRON TRANSFER AND OXIDATIVE PHOSPHORYLATION.

 

5.1 Historical Introduction.

 

5.2 The Electron Transport Chain.

 

5.3 Electron Transport in Other Organisms.

 

5.4 The Chemiosmotic Hypothesis.

 

5.5 ATP Synthase (F1Fo-ATPase).

 

5.6 Control of Respiration and Oxidative Phosphorylation.

 

5.7. Reactive Oxygen Species.

 

5.8 Nitric Oxide (NO).

 

5.9 The Role of Specific Lipids.

 

References.

 

VI. METABOLIC PATHWAYS INSIDE MITOCHONDRIA.

 

6.1 Introduction.

 

6.2 The Krebs Cycle.

 

6.3 Fatty Acid Metabolism.

 

6.4 The Urea Cycle.

 

6.5 Biosynthesis of Heme.

 

6.6 Cardiolipin and Lipid Biosynthesis/Metabolism.

 

6.7 Biosynthesis of Ubiquinol (Coenzyme Q).

 

6.8 Biosynthesis of Fe-S Centers.

 

6.9 Transport of small solutes into and out of mitochondria.

 

References.

 

VII. MITOCHONDRIAL MUTATIONS AND DISEASE.

 

7.1 General Introduction.

 

7.2 In Cell Culture.

 

7.3 Molecular Genetics of Human Mitochondrial Diseases.

 

7.4 Mitochondrial DNA and Aging.

 

7.5 Mitochondria and Apoptosis.

 

7.6 Fungal Senescence.

 

7.7 Cytoplasmic Male Sterility in Plants.

 

References.

 

VIII. MITOCHONDRIAL DNA SEQUENCING AND ANTHROPOLOGY.

 

8.1 Introduction.

 

8.2 Human Evolution.

 

8.3 Primate Evolution.

 

8.4 Human Y chromosome variation.

 

8.5 Forensic Applications.

 

8.6 Future Challenges.

 

References.

 

IX. MITOCHONDRIA AND PHARMACOLOGY.

 

9.1. Introduction.

 

References.