Zweigstelle	Standorte	Status	Vorbestellungen	Frist	Barcode	Lageplan	Ausleihhinweis
Zweigstelle: Hauptstelle	Standorte: SP-20 27	Status: Verfügbar	Vorbestellungen: 0	Frist:	Barcode: 00175307	Lagepläne: Lageplan	Ausleihhinweis:

Contents

Preface

Introduction

Chapter 1: What Instrumental Approaches are available

1.1 Ion Sources

1.1.1 Electron Ionization

1.1.2 Chemical Ionization

1.1.3 Atmospheric Pressure Chemical Ionization

1.1.4 Electrospray Ionization

1.1.5 Atmospheric Pressure Photoionization

1.1.6 Matrix-Assisted Laser Desorption/Ionization

1.2 Mass Analyzers

1.2.1 Mass resolution

1.2.2 Sector Analyzers

1.2.3 Quadrupole analyzers

1.2.3.1 Quadrupole mass filter

1.2.3.2 Quadrupole ion trap

1.2.4 Time-of-flight

1.3 GC/MS

1.3.1 Total ion current (TIC) chromatogram

1.3.2 Reconstructed ion chromatogram (RIC)

1.3.3 Multiple ion detection (MID)

1.4 LC/MS

1.5 MS/MS (IT, QQQ, QTOF, TOF/TOF)

1.5.1 MS/MS by double focusing instruments

1.5.2 MS/MS by triple quadrupoles

1.5.3 MS/MS by ion traps

1.5.4 MS/MS by Q-TOF

Chapter 2: How to design a Quantitative analysis

2.1 General strategy:

2.1.1 Project

2.1.2 Sampling

2.1.3 Sample treatment

2.1.4 Instrumental analysis

2.1.4.1 Quantitative analysis by GC/MS and LC/MS

2.1.4.2 Calibration curves

2.1.4.3 Internal standard

Chapter 3: How to improve specificity.

3.1 Choice of the suitable chromatographic procedures

3.1.1 GC/MS measurements in low and high resolution conditions

3.1.1.1. An example of GC/MS application of biological interest of biomedical interest: quantitative determination of glyoxale and methylglyoxale in plasma samples.

3.1.2 LC/ESI/MS and LC/APCI/MS.

3.2 Choice of the suitable ionization method

3.3 Use of high specificity and selectivity methods: an example: the dioxin analysis

3.3.1 Use of high resolution MID analysis

3.3.2 Negative ion chemical ionization in the analysis of dioxins, furans and PCBs

3.3.3 MS/MS in the detection of dioxins, furans and PCBs

Chapter 4: Some thoughts on calibration and data analysis

4.1 Calibration designs

4.2 Homoscedastic and heteroscedastic data

4.2.1 Variance model

4.3 Calibration models

4.3.1 Unweighted regression

4.3.2 Straight line calibration curve

4.3.3 Discrimination

4.3.3.1 Detection and quantification limits

4.3.4 Quadratic calibration curve

4.4

4.4.1 Weighted regression

4.4.1.1 Weighted straight line calibration curve

4.4.1.2 Discrimination and detection limits

4.4.1.3 Weighted quadratic calibration curve

4.5 Different approaches to estimate detection and quantification limits

Index