Zweigstelle	Standorte	Status	Vorbestellungen	Frist	Barcode	Lageplan	Ausleihhinweis
Zweigstelle: Hauptstelle	Standorte: GE-30 155	Status: Verfügbar	Vorbestellungen: 0	Frist:	Barcode: 00263621	Lagepläne: Lageplan	Ausleihhinweis:

One of the foundations of molecular biology is how the interactions of proteins with DNA control many aspects of gene expression. Since the mid-20th century, from discoveries of the lac repressor and operator and the competition between the cI and cro proteins for the same segment of DNA, we have learned an enormous amount about the interactions of proteins with DNA and their control of fundamental processes in the cell. Introduction to Protein–DNA Interactions: Structure, Thermodynamics, and Bioinformatics describes what we know about protein–DNA interactions from the complementary perspectives of molecular and structural biology and bioinformatics and how each perspective informs the others. A particular emphasis is on how insights from experimental work can be translated into specific computational approaches to create a unified view of the field and a fuller understanding of protein–DNA interactions.

TOC:

Preface

 

1 Importance of Protein–DNA Interactions

 

STRUCTURE

 

2 The Structure of DNA

3 Protein Structure and DNA Recognition

4 Sequence-Specific Interactions in Protein–DNA Complexes

 

THERMODYNAMICS

 

5 Binding Affinity, Cooperativity, and Specificity

6 Energetics and Kinetics of Binding

 

BIOINFORMATICS

 

7 Bioinformatics of DNA-Binding Sites

8 Bioinformatics of Transcription Factors and Recognition Models

9 Transcriptional Genomics

 

Index