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Kurzbeschreibung

Here, expert scientists from industry and academia share their knowledge on the assembly of functional human tissues in vitro and how to design drug screenings predictive of human exposure. In so doing, they combine the latest technological developments with strategic outlooks, while tackling such important issues as regulatory acceptance and ethical considerations.

 

Aus dem Inhalt

Foreword (Rolf Krebs)

Preface

List of Contributors

PART I EMERGING IN-VITRO CULTURE TECHNOLOGIES

Intelligent Biomatrices and Engineered Tissue Constructs: In-Vitro Models for Drug Discovery and Toxicity Testing (Philip Lazarovici, Mengyan Li, Anat Perets, Mark J. Mondrinos, Shimon Lecht, Christopher D. Koharski, Paul R. Bidez III, Christine M. Finck, and Peter I. Lelkes)

An Overview on Bioreactor Design, Prototyping and Process Control for Reproducible Three-Dimensional Tissue Culture (Ralf Pörtner and Christoph Giese)

An Overview on Bioelectronic and Biosensoric Microstructures Supporting High-Content Screening in Cell Cultures (Andrea A. Robitzki and Andrée Rothermel)

Novel In-Vitro Exposure Techniques for Toxicity Testing and Biomonitoring of Airborne Contaminants (Amanda Hayes, Shahnaz Bakand, and Chris Winder)

PART II PRIMARY TISSUES AND CELL LINES IN DRUG SCREENING/TESTING

Drug Screening Using Cell Lines: Cell Supply, High-Throughput and High-Content Assays (Christa Burger, Oliver Pöschke, and Mirek R. Jurzak)

Cell Lines and Primary Tissues for In-Vitro Evaluation of Vaccine Efficacy (Anthony Meager)

Designer Cells Derived from Primary Tissue and Designed Cell Lines as a Sustainable Cell Source for Drug Discovery and Safety Assessment (Volker Sandig and Ingo Jordan)

How Human Embryonic Stem Cell Research Can Impact In-Vitro Drug Screening Technologies of the Future (André Schrattenholz and Martina Klemm)

PART III THE USE OF HUMAN TISSUES IN DRUG DISCOVERY: SCIENTIFIC, ETHICAL, LEGAL, AND REGULATORY ENVIRONMENTS

Availability, Standardization and Safety of Human Cells and Tissues for Drug Screening and Testing (Glyn N. Stacey and Thomas Hartung)

Ethical Environment and Scientific Rationale Towards In-Vitro Alternatives to Animal Testing: Where Are We Going? (Horst Spielmann)

PART IV SUMMARY AND VISIONS

How Drug Development of the 21st Century Could Benefit from Human Micro-Organoid In-Vitro Technologies (Uwe Marx)

Subject Index