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Ideal for the student seeking a solid understanding of the basic principles in this rapidly developing field, this best-selling text offers a comprehensive introduction to the fundamentals of virology. Featuring an enhanced art program now in full-color, the new edition has been updated throughout.

 

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Preface to the First Edition.

 

Preface to the Second Edition.

 

Preface to the Third Edition.

 

Acknowledgments.

 

Part I: Virology and Viral Disease.

 

1. Introduction - the Impact of Viruses on Our View of Life 2.

 

2. An Outline of Virus Replication and Viral Pathogenesis.

 

3. Virus Disease in Populations and Individual Animals.

 

4. Patterns of Some Viral Diseases of Humans.

 

Part II: Basic Properties of Viruses and Virus-Cell Interaction.

 

5. Virus Structure and Classification.

 

6. The Beginning and End of the Virus Replication Cycle.

 

7. Host Immune Response to Viral Infection - The Nature of the Vertebrate Immune Response.

 

8. Strategies to Protect Against and Combat Viral Infection.

 

Part III: Working with Virus.

 

9. Visualization and Enumeration of Virus Particles.

 

10. Replicating and Measuring Biological Activity of Viruses.

 

11. Physical and Chemical Manipulation of the Structural Components of Viruses.

 

12. Characterization of Viral Products Expressed in the Infected Cell.

 

13. Viruses Use Cellular Processes to Express Their Genetic Information.

 

Part IV: Replication Patterns of Specific Viruses.

 

14. Replication of Positive-sense RNA Viruses.

 

15. Replication Strategies of RNA Viruses Requiring RNA-directed mRNA Transcription as the First Step in Viral Gene Expression.

 

16. Replication Strategies of Small and Medium-sized DNA Viruses.

 

17. Replication of Some Nuclear-replicating Eukaryotic DNA Viruses with Large Genomes.

 

18. Replication of Cytoplasmic DNA Viruses and "Large" Bacteriophages.

 

19. Retroviruses: Converting RNA to DNA.

 

20. Human Immunodeficiency Virus Type 1 (HIV-1) and Related Lentiviruses.

 

21. Hepadnaviruses: Variations on the Retrovirus Theme.

 

PART V: Viruses: New Approaches and New Problems.

 

22. The Molecular Genetics of Viruses.

 

23. Molecular Pathogenesis.

 

24. Viral Bioinformatics and Beyond.

 

25. Viruses and the Future - Promises and Problems.

 

Appendix: Resource Center.

 

Books of Historical and Basic Value.

 

Books on Virology.

 

Molecular Biology and Biochemistry Texts.

 

Detailed Sources.

 

Sources for Experimental Protocols.

 

The Internet.

 

Technical Glossary.

 

Index