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This book provides an in-depth analysis of the mechanisms and biological consequences of genome rearrangements in bacteria. Genome rearrangements are a result of the actions of discrete genetic elements such as conjugative transposons, plasmids, phage, and non-conjugative transposons. Bacteria also contain systems to mediate genetic rearrangements such as the general recombination pathway and specialized endogenous recombination mechanisms. The biological effects of these rearrangements are far-reaching and impact on bacterial virulence, antibiotic resistance and the ability of bacteria to avoid the attentions of the host immune system (e.g. antigenic variation). These rearrangements also provide the raw material on which natural selection can act. Each chapter examines the mechanisms involved in genome rearrangements and the direct biological consequences of these events. This book is written by leading research workers and is an invaluable resource for graduate students and researchers in this field.

Table of Contents

Part I. Basic Mechanisms of Genome Rearrangement in Bacteria: 1. Mechanisms of homologous recombination in bacteria Marie-Agnès Petit

2. Introduction to site-specific recombination Makkuni Jayaram and Ian Grainge

3. Site-specific recombination by the serine recombinases Sally J. Rowland and W. Marshall Stark

4. Mobile introns and retroelements in bacteria Steve Zimmerly

Part II. Horizontal Gene Transfer and Genome Plasticity: 5. The F-Plasmid, a paradigm for bacterial conjugation Michael J. Gubbins, William R. Will and Laura S. Frost

6. Molecular aspects of movement of conjugative transposons Adam P. Roberts and Peter Mullany

7. Competence for genetic transformation Irena Draskovic and David Dubnau

Part III. Biological Consequences of the Mobile Genome: 8. Phase variation and antigenic variation Richard Villemur and Eric Déziel

9. Pathogenicity islands Bianca Hochhut and Jörg Hacker

10. Biological consequences for bacteria of homologous recombination Diarmaid Hughes and Tobias Norström

11. Horizontal gene transfer and bacterial genomic legacies James R. Brown.