Zweigstelle	Standorte	Status	Vorbestellungen	Frist	Barcode	Lageplan	Ausleihhinweis
Zweigstelle: Hauptstelle	Standorte: ME-20 114	Status: Entliehen	Vorbestellungen: 0	Frist: 24.10.2023	Barcode: 00318353	Lagepläne: Lageplan	Ausleihhinweis:

This is the first book to deal with the theoretical aspects and with the clinical applications of pharmacokinetic and pharmacodynamic modeling in the field of antimicrobial drug therapy

 

Numerous subjects will be discussed including basic pharmacodynamic theory, pharmacokinetic complexities, and the use of in vitro and animal PK/PD models.Over the past decade, significant progress has been made in the theory and applications of pharmacodynamics of antimicrobial agents. On the basis of pharmacokinetic-pharmacodynamic modeling concepts it has become possible to describe and predict the time course of antimicrobial effects under normal and pathophysiological conditions. The study of pharmacokinetic-pharmacodynamic relationships can be of considerable value in understanding drug action, defining optimal dosing regimens, and in making predictions under new or changing pre-clinical and clinical circumstances. Not surprisingly, pharmacokinetic-pharmacodynamic modeling concepts are increasingly applied in both basic and clinical research as well as in drug development. Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics is designed as a reference on the application of pharmacokinetic-pharmacodynamic principles for the optimization of antimicrobial therapy, namely pharmacotherapy, and infectious diseases. The reader is introduced to various aspects of the fundamentals of antimicrobial pharmacodynamics, the integration of pharmacokinetics with pharmacodynamics for all major classes of antibiotics, from basic research to clinical situations.

TOC:

Foreword

Section I: Basic Concepts and Principles

Introduction to Pharmacodynamics and micrbiology

In vitro and animal PK/PD model

MIC and breakpoints

Principles of applied PK/PD modeling

Population Pk/PD modeling and its applications to antimicrobials

Drug resistance and Drug-drug combinations

Section II: Clinical

Aminoglycosides

Beta-lactam antibiotics including continuous infusion

Macrolides

Glycopeptides

Quinolones

Other.-

 

Includes supplementary material: https://extras.springer.com/?query=978-0-387-75612-7