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Genome Science is a textbook and laboratory manual for advanced secondary and post-secondary education. It combines approachable narrative with extensively tested lab exercises that illustrate key concepts of genome biology in humans, invertebrates, and plants. Nineteen labs, organized into four chapters, engage students with both bioinformatics exercises and in vitro experiments. Each chapter also includes an extensive introduction that provides an historical and conceptual framework. This modular structure offers many options for enhancing existing courses, starting new courses, or supporting student research projects. The book is complete with advice for instructors, laboratory planning guidelines, recipes for solutions, and answers to student questions.

TOC:

 

1. Genome as Information

Introduction

Lab 1.1 Annotating Genomic DNA

Lab 1.2 Detecting a Lost Chromosome

Lab 1.3 Comparing Diversity in Eukaryotes

Lab 1.4 Determining the Transposon Content in Grasses

Lab 1.5 Identifying GAI Gene Family Members in Plants

Lab 1.6 Discovering Evidence for Pseudogene Function

Laboratory Planning and Preparation

Answers to Questions

 

2. The Human Genome

Introduction

Lab 2.1 Using Mitochondrial DNA Polymorphisms in Evolutionary Biology

Lab 2.2 Using an Alu Insertion Polymorphism to Study Human Populations

Lab 2.3 Using a Single-Nucleotide Polymorphism to Predict Bitter-Taste Ability

Laboratory Planning and Preparation

Recipes for Reagents and Stock Solutions

Answers to Questions

 

3. Plant Genomes

Introduction

Lab 3.1 Detecting a Transposon in Corn

Lab 3.2 Detecting a Transposon in Arabidopsis

Lab 3.3 Linkage Mapping a Mutation

Lab 3.4 Detecting Genetically Modified Foods by Polymerase Chain Reaction

Lab 3.5 Using DNA Barcodes to Identify and Classify Living Things

Lab 3.6 Detecting Epigenetic DNA Methylation in Arabidopsis

Laboratory Planning and Preparation

Recipes for Reagents and Stock Solutions

Answers to Questions

 

 

4. Genome Function

Introduction

Lab 4.1 Culturing and Observing C. elegans

Lab 4.2 Using E. coli Feeding Strains to Induce RNAi and Knock Down Genes

Lab 4.3 Examining the RNAi Mechanism

Lab 4.4 Constructing an RNAi Feeding Vector

Laboratory Planning and Preparation

Recipes for Reagents and Stock Solutions

Answers to Questions

 

Cautions Appendix

Equipment Appendix

Subject Index