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Antimalarial natural products

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Author: Search for this author Kingston, David G. I. (author); Belen Cassera, Maria (author)
Year: [2022]
Publisher: Cham, Springer Nature Switzerland AG
Media group: Serien
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Content

This volume begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine’s biosynthesis, its mechanism of action, and its clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine’s structure. It also covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, including summaries of its synthesis and biosynthesis, its mechanism of action, and its clinical use and resistance. A short discussion of other clinically used antimalarial natural products leads to a detailed treatment of additional natural products with significant antiplasmodial activity, classified by compound type. Although the search for new antimalarial natural products from Nature’s combinatorial library is challenging, it is very likely to yield new antimalarial drugs. This book thus ends by identifying ten natural products with development potential as clinical antimalarial agents.

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Details

Statement of Responsibility: by David G. I. Kingston and Maria Belen Cassera
Year: [2022]
Publisher: Cham, Springer Nature Switzerland AG
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Classification: Search for this systematic NA-10, MB-40
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ISBN: 9783030898724
ISBN (2nd): 3030898725
Description: ix, 106 Seiten, Diagramme, Illustrationen
Tags: Medizinische Mikrobiologie, Naturstoffe allgemein
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Language: Englisch
Media group: Serien