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Hepatitic C virus

the story of a scientific and therapeutic revolution
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Year: 2020
Publisher: Cold Spring Harbor, NY, Cold Spring Harbor Laboratory Press
Media group: Ausleihbestand
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Branch: Hauptstelle Locations: MB-40 315 / Ausstellungsregal Status: available Reservations: 0 Due date: Barcode: 00307629 Floor plans: Floor plan Lending note:

Content

Hepatitis C is a liver disease caused by infection with the hepatitis C virus (HCV), a bloodborne pathogen. In some people, an immune response will clear the infection; however, in most, the infection becomes chronic and treatment with antiviral medication is necessary to prevent serious liver damage and cancer. The eradication of HCV will require improved access to diagnosis and treatment, an enhanced understanding of virus-host interactions, and the development of an effective vaccine.
 
Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines all aspects of the biology of HCV, the pathological consequences of infection, the current standard of hepatitis C treatment, and ongoing efforts to control the disease. Contributors discuss the structural and biochemical properties of HCV, the molecular details of its life cycle, and how it promotes liver disease by perturbing host cell signaling pathways. They likewise examine the innate and adaptive immune responses elicited by HCV and why those responses often fail to clear the infection. Direct-acting antiviral regimens to treat infected patients, the impacts of those treatments on hepatitis C epidemiology, and obstacles to HCV elimination (e.g., vaccine development) are also covered.
 
This volume includes additional perspectives on the discovery of HCV, historical milestones in HCV research, and animal and cell culture models of HCV infection. It is an essential reference for virologists, immunologists, and all clinical and laboratory investigators interested in eliminating HCV as a public health threat.

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Statement of Responsibility: edited by Arash Grakoui, Emory Universiyt, Jean-Michel Pawlotsky, University of Paris-Est, Glenn Randall, University of Chicago
Year: 2020
Publisher: Cold Spring Harbor, NY, Cold Spring Harbor Laboratory Press
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Classification: Search for this systematic MB-40, VI-20
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ISBN: 9781621823193
ISBN (2nd): 1621823199
Description: vii, 297 Seiten, Diagramme, Illustrationen
Tags: Medizinische Mikrobiologie, Tierische Viren
Participating parties: Search for this character Grakoui, Arash (editor); Pawlotsky, Jean-Michel (editor); Randall, Glenn (editor)
Language: Englisch
Original title: Hepatitis C virus
Media group: Ausleihbestand