Contents
1 Approach to Medicine, the Patient and the Medical Profession: Medicine as a Learned and Humane Profession
2 Bioethics in the Practice of Medicine
3 Care of Dying Patients and Their Families
4 Cultural Context of Medicine
5 Socioeconomic Issues in Medicine
6 Approach to the Patient: History and Physical Examination
7 Approach to the Patient with Abnormal Vital Signs
8 Statistical Interpretation of Data
9 Using Data for Clinical Decisions
10 Principles of Outcome Assessment
11 Patient Safety and Quality of Care
12 Principles of Preventive Health Care
13 The Periodic Health Examination
14 Physical Activity
15 Violence and Injury
16 Immunization
17 Principles of Occupational and Environmental Medicine
18 Radiation Injury
19 Bioterrorism
20 Chronic Poisoning: Trace Metals and Others
21 Epidemiology of Aging: Implications of the Aging of Society
22 Biology of Aging
23 Common Clinical Sequelae of Aging
24 Urinary Incontinence
25 Neuropsychiatric Aspects of Aging
26 Delirium and Other Mental Status Problems in the Older Patient
27 Principles of Drug Therapy
28 Pain
29 Biology of Addiction
30 Tobacco
31 Alcohol Abuse and Dependence
32 Drug Abuse and Dependence
33 Immunosuppressing Drugs Including Glucocorticoids
34 Prostaglandins, Aspirin, and Related Compounds
35 Antithrombotic Therapy
36 Complementary and Alternative Medicine
37 Principles of Genetics: Overview of the Paradigm of Genetic Contribution to Health and Disease
38 Genetic Risk Assessment
39 Single Gene and Chromosomal Disorders
40 The Inherited Basis of Common Diseases
41 Gene and Cell Therapy
42 The Innate and Adaptive Immune Systems
43 The Major Histocompatibility Complex and Disease Susceptibility
44 Mechanisms of Immune-Mediated Tissue Injury
45 Mechanisms of Inflammation and Tissue Repair
46 Transplant Immunology
47 Complement in Health and Disease
48 Approach to the Patient with Possible Cardiovascular Disease
49 Epidemiology of Cardiovascular Disease
50 Cardiac Function and Circulatory Control
51 Radiology of the Heart
52 Electrocardiography
53 Echocardiography
54 Nuclear Cardiology and Computed Tomography
55 Cardiac Magnetic Resonance Imaging
56 Catheterization and Angiography
57 Heart Failure: Pathophysiology and Diagnosis
58 Heart Failure: Management and Prognosis
59 Diseases of the Endocardium and Myocardium
60 Principles of Electrophysiology
61 Approach to the Patient with Suspected Arrhythmia
62 Approach to Cardiac Arrest and Life-Threatening Arrhythmias
63 Cardiac Arrhythmias with Supraventricular Origin
64 Ventricular Arrhythmias and Approach to the Survivor of Cardiac Arrest
65 Electrophysiologic Interventional Procedures and Surgery
66 Arterial Hypertension
67 Pulmonary Hypertension
68 Congenital Heart Disease in Adults
69 Atherosclerosis, Thrombosis, and Vascular Biology
70 Angina Pectoris
71 Acute Coronary Syndrome: Unstable Angina and Non-ST Segment Elevation Myocardial Infarction
72 ST-Elevation Acute Myocardial Infarction and Complications of Myocardial Infarction
73 Percutaneous Coronary Interventions
74 Surgical Treatment of Coronary Artery Disease
75 Valvular Heart Disease
76 Infective Endocarditis
77 Pericardial Disease
78 Diseases of the Aorta
79 Atherosclerotic Peripheral Arterial Disease
80 Other Peripheral Arterial Diseases
81 Peripheral Venous Disease
82 Cardiac Transplantation
83 Approach to the Patient with Respiratory Disease
84 Imaging in Pulmonary Disease
85 Respiratory Structure and Function
86 Disorders of Ventilatory Control
87 Asthma
88 Chronic Obstructive Pulmonary Disease
89 Cystic Fibrosis
90 Bronchiectasis and Localized Airway/Parenchymal Disorders
91 Alveolar Filling Disorders
92 Interstitial Lung Disease
93 Occupational Pulmonary Disorders
94 Physical, Chemical, and Aspiration Injuries of the Lung
95 Sarcoidosis
96 Acute Bronchitis and Tracheitis
97 Approach to the Patient with Pneumonia
98 Lung Abscess
99 Pulmonary Embolism
100 Diseases of the Diaphragm, Chest Wall, Pleura, and Mediastinum
101 Obstructive Sleep Apnea and Hypopnea Syndromes
102 Surgical Approach to Lung Disease
103 Approach to the Patient in a Critical Care Setting
104 Respiratory Monitoring in Critical Care
105 Acute Respiratory Failure
106 Ventilator Management in the Intensive Care Unit
107 Approach to the Patient with Shock
108 Cardiogenic Shock
109 Shock Syndromes Related to Sepsis
110 Disorders Due to Heat and Cold
111 Acute Poisoning
112 Electric Injury
113 Medical Aspects of Trauma and Burn Care
114 Rhabdomyolysis
115 Approach to the Patient with Renal Disease
116 Structure and Function of the Kidneys
117 Total Body Fluids
118 Potassium Balance Disorders
119 Acid-Base Disorders
120 Disorders of Magnesium and Phosphorus
121 Acute Renal Failure
122 Glomerular Disorders and Nephrotic Syndromes
123 Tubulointerstitial Diseases
124 Obstructive Uropathy
125 Diabetes and the Kidney
126 Vascular Disorders of the Kidney
127 Renal Calculi (Nephrolithiasis)
128 Cystic Diseases of the Kidney
129 Hereditary Nephropathies and Abnormalities of the Urinary Tract
130 Benign Prostate Disease and Prostatitis
131 Chronic Renal Failure
132 Renal Osteodystrophy
133 Treatment of Irreversible Renal Failure
134 Approach to the Patient with Gastrointestinal Disease
135 Diagnostic Imaging Procedures in Gastroenterology
136 Gastrointestinal Endoscopy
137 Gastrointestinal Hemorrhage and Occult Gastrointestinal Bleeding
138 Disorders of Gastrointestinal Motility
139 Functional Gastrointestinal Disorders: Irritable Bowel, Non-Ulcer Dyspepsia, and Noncardiac Chest Pain
140 Diseases of the Esophagus
141 Pathophysiology of Acid Peptic Disease
142 Diagnosis and Treatment of Acid Peptic Disease
143 Approach to the Patient with Diarrhea and Malabsorption Syndromes
144 Inflammatory Bowel Disease
145 Appendicitis, Diverticulitis, and Inflammatory Diseases of the Intestine, Peritoneum, Mesentery, and Omentum
146 Vascular Diseases of the Intestine
147 Pancreatitis
148 Diseases of the Rectum and Anus
149 Approach to the Patient with Liver Disease
150 Approach to the Jaundiced Patient and or Abnormal Liver Tests
151 Acute Viral Hepatitis
152 Chronic Hepatitis
153 Toxin and Drug-Induced Liver Disease
154 Inherited, Infiltrative, and Metabolic Disorders Involving the Liver
155 Bacterial, Parasitic, Fungal, and Granulomatous Liver Diseases
156 Alcoholic and Non-Alcoholic Steatohepatitis
157 Cirrhosis and Its Sequelae
158 Hepatic Failure and Liver Transplantation
159 Diseases of the Gallbladder and Bile Ducts
160 Hematopoiesis and Hematopoietic Growth Factors
161 The Peripheral Blood Smear
162 Approach to the Anemias
163 Microcytic and Hypochromic Anemias
164 Autoimmune and Intravascular Hemolytic Anemias
165 Hemolytic Anemias: Red Cell Membrane and Metabolic Defects
166 The Thalassemias
167 Sickle Cell Anemia and Associated Hemoglobinopathies
168 Hemoglobinopathies: Methemoglobinemias, Polycythemias, and Unstable Hemoglobins
169 Nonhemolytic Normochromic, Normocytic Anemias
170 Megaloblastic Anemias
171 Aplastic Anemia and Related Disorders
172 Polycythemias and Unstable Hemoglobins
173 Leukopenia and Leukocytosis
174 Approach to the Patient with Lymphadenopathy and Splenomegaly
175 Disorders of Phagocyte Function
176 Eosinophilic Syndromes
177 Chronic Myeloproliferative Disorders: Essential Thrombocythemia and Myelofibrosis with Myeloid Metaplasia
178 Approach to the Patient with Bleeding and Thrombosis
179 Hemorrhagic Disorders: Abnormalities of Platelet and Vascular Function
180 Hemorrhagic Disorders: Coagulation Factor Deficiencies
181 Hemorrhagic Disorders: Disseminated Intravascular Coagulation, Liver Disease, and Vitamin K Deficiency
182 Thrombotic Disorders and Hypercoagulable States
183 Transfusion Medicine
184 Hematopoietic Stem Cell Transplantation
185 Epidemiology of Cancer
186 Genetics of Cancer
187 Biology of Cancer
188 Endocrine Manifestations of Tumors: Ectopic Hormone Production
189 Paraneoplastic Syndromes and Other Non-neoplastic Effects of Cancer
190 Tumor Markers
191 Cancer Prevention
192 Principles of Cancer Therapy
193 Myelodysplastic Syndrome
194 The Acute Leukemias
195 The Chronic Leukemias
196 Non-Hodgkin's Lymphomas
197 Hodgkin's Disease
198 Plasma Cell Disorders
199 Tumors of the Central Nervous System and Intracranial Hypertension and Hypotension
200 Head and Neck Cancer
201 Lung Cancer and Other Pulmonary Neoplasms
202 Neoplasms of the Esophagus and Stomach
203 Neoplasms of the Large and Small Intestine
204 Carcinoma of the Pancreas
205 Pancreatic Endocrine Tumors
206 Liver and Biliary Tract Tumors
207 Tumors of the Kidney, Bladder, Ureters, and Renal Pelvis
208 Breast Cancer and Differential Diagnosis of Benign Nodules
209 Gynecologic Cancers
210 Testicular Cancer
211 Prostate Cancer
212 Bone Sarcomas
213 Soft Tissue Sarcoma
214 Melanoma and Nonmelanoma Skin Cancers
215 Cancer of Unknown Primary Origin
216 Approach to the Patient with Inborn Errors of Metabolism
217 Disorders of Lipid Metabolism
218 Galactosemia
219 Glycogen Storage Diseases
220 Fructose Intolerance
221 Primary Hyperoxaluria
222 Disorders of Purine and Pyrimidine Metabolism
223 Lysosomal Storage Diseases
224 Disorders of Phenylalanine and Tyrosine Metabolism
225 The Hyperprolinemias and Hydroxyprolinemia
226 Diseases of the Urea Cycle
227 Branched Chain Aminoacidurias
228 Homocystinuria
229 The Porphyrias
230 Wilson's Disease
231 Iron Overload (Hemochromatosis)
232 Nutrition's Interface with Health and Disease
233 Nutritional Assessment
234 Protein-Energy Malnutrition
235 Enteral Nutrition
236 Parenteral Nutrition
237 Vitamins and Micronutrients
238 The Eating Disorders
239 Obesity
240 Principles of Endocrinology
241 Neuroendocrinology and the Neuroendocrine System
242 Anterior Pituitary
243 Posterior Pituitary
244 The Thyroid
245 The Adrenal Cortex
246 The Adrenal Medulla, Catecholamines, and Pheochromocytoma
247 Diabetes Mellitus - Type I and Complications
248 Diabetes Mellitus - Type II, Including Metabolic Syndrome
249 Hypoglycemia/Pancreatic Islet Cell Disorders
250 Polyglandular Disorders
251 Carcinoid Syndrome
252 Disorders of Sexual Differentiation
253 The Testis and Male Sexual Function
254 Approach to Women's Health
255 Ovaries and Development
256 Menstrual Cycle and Fertility
257 Contraception
258 Neoplastic Diseases in Pregnancy
259 Hypertension and Common Medical Problems in Pregnancy
260 HIV in Pregnancy
261 Hirsutism
262 Menopause
263 Mineral and Bone Homeostasis
264 Osteoporosis
265 Osteomalacia and Rickets
266 The Parathyroid Glands, Hypercalcemia, and Hypocalcemia
267 Medullary Thyroid Carcinoma and Calcitonin
268 Paget's Disease of Bone (Osteitis Deformans)
269 Osteonecrosis, Osteosclerosis/Hyperostosis and Other Disorders of Bone
270 Approach to the Patient with Allergic or Immunologic Disease
271 Primary Immunodeficiency Diseases
272 Allergic Rhinosinusitis and Chronic Sinusitis
273 Urticaria and Angioedema
274 Systemic Anaphylaxis, Food Allergy, and Insect Sting Allergy
275 Drug Allergy
276 Mastocytosis
277 Approach to the Patient with Rheumatic Disease
278 Laboratory Testing in Rheumatic Diseases
279 Imaging Studies in Rheumatic Diseases
280 Connective Tissue Structure and Function
281 Inherited Diseases of Connective Tissues
282 Inherited Inflammatory Disorders
283 Osteoarthritis
284 Bursitis, Tendonitis, and Other Periarticular Disorders, and Sports Medicine
285 Rheumatoid Arthritis
286 The Spondyloarthropathies
287 Systemic Lupus Erythematosus
288 Scleroderma (Systemic Sclerosis)
289 Sj gren's Syndrome
290 Polymyositis and Dermatomyositis
291 The Systemic Vasculitides
292 Polymyalgia Rheumatica and Temporal Arteritis
293 Infections of Bursae, Joints, and Bones
294 Crystal Deposition Diseases
295 Fibromyalgia and Chronic Fatigue Syndrome
296 Amyloidosis
297 Systemic Diseases in which Arthritis is a Feature
298 Multifocal Fibrosclerosis
299 Surgical Treatment of Joint Diseases
300 Emerging and Re-emerging Infectious Disease Threats
301 Host-Pathogen Interactions
302 Principles of Anti-infective Therapy
303 Approach to Fever or Suspected Infection in the Normal Host
304 Approach to Fever or Suspected Infection in the Compromised Host
305 Approach to the Patient with Healthcare-associated Infections
306 Approach to the Patient with Suspected Enteric Infection
307 Approach to the Patient with Urinary Tract Infection
308 Approach to the Patient with a Sexually Transmitted Disease
309 Approach to the Patient Before and After Travel
310 Antibacterial Therapy
311 Staphylococcal Infections
312 Streptococcus pneumoniae Infections
313 Non-pneumococcal Streptococcal Infections
314 Rheumatic Fever
315 Enterococcal Infections
316 Diphtheria and Other Corynebacteria Infections
317 Listeria Infections
318 Anthrax and Other Bacillus Infections
319 Erysipelothrix Infections
320 Clostridial Infections
321 Non-spore-forming Anaerobic and Mixed Anaerobic Infections
322 Neisseria meningitidis Infections
323 Neisseria gonorrhoeae Infections
324 Hemophilus influenzae and Moraxella Infections
325 Hemophilus ducreyi Infections (Chancroid)
326 Cholera and Other Vibrio Infections
327 Campylobacter Infections
328 Escherichia coli and Other Enterobacteriaceae Infections
329 Pseudomonas and related Gram-negative Bacillary Infections
330 Salmonella Infections
331 Shigella Infections
332 Brucella Infections
333 Tularemia and Other Francisella Infections
334 Plague and Other Yersinia Infections
335 Whooping Cough and Other Bordetella Infections
336 Legionella Infections
337 Bartonella Infections
338 Granuloma Inguinale (Donovanosis)
339 Mycoplasma Infection
340 Chlamydia Infections
341 Treponema Infection (Syphilis)
342 Nonsyphilitic Treponema Infections
343 Borrelia burgdorferi Infection (Lyme Disease)
344 Relapsing Fever and Other Borrelia Infections
345 Leptospira Infection
346 Tuberculosis
347 Other Mycobacterioses
348 Leprosy (Hansen's Disease)
349 Rickettsia Infections
350 Zoonoses
351 Actinomycosis
352 Nocardiosis
353 Antifungal Therapy
354 Histoplasmosis
355 Coccidioidomycosis
356 Blastomycosis
357 Paracoccidioidomycosis
358 Cryptococcosis
359 Sporotrichosis
360 Candidiasis
361 Aspergillosis
362 Mucormycosis
363 Pneumocystis carinii
364 Mycetoma
365 Dematiaceous Fungal Infection
366 Antiparasitic Therapy
367 Malaria
368 African Trypanosomiasis (Sleeping Sickness)
369 American Trypanosomiasis (Chagas' Disease)
370 Leishmaniasis
371 Toxoplasmosis
372 Cryptosporidiosis
373 Giardiasis
374 Amebiasis
375 Babesiosis and Other Protozoan Diseases
376 Cestode Infections
377 Schistosomiasis (Bilharziasis)
378 Liver, Intestinal, and Lung Fluke Infections
379 Nematode Infections
380 Filariasis
381 Arthropods and Leeches
382 Venomous Snake Bites
383 Venoms and Poisons from Marine Organisms
384 Antiviral Therapy (Non-AIDS)
385 Rhinovirus
386 Respiratory Syncytial Virus
387 Parainfluenza Viral Diseases
388 Influenza Virus
389 Adenovirus
390 Coronavirus
391 Rubeola Virus (Measles)
392 Rubella (German Measles)
393 Mumps Virus
394 Slow Virus Infections
395 Parvovirus
396 Smallpox, Monkeypox, and Other Poxviruses
397 Papillomavirus
398 Herpes Simplex and Other Human Herpesviruses
399 Varicella-Zoster Virus (Chickenpox, Shingles)
400 Cytomegalovirus
401 Epstein-Barr Virus Infection