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Powerful new techniques have revolutionized the field of molecular biology. The vast amount of DNA sequence information produced by next-generation sequencers demands new bioinformatics algorithms to analyze the data.

This book provides an introduction to algorithms and data structures that operate efficiently on strings (especially those used to represent long DNA sequences). It focuses on algorithms for sequence analysis (string algorithms), but also covers genome rearrangement problems and phylogenetic reconstruction methods.

 

Topics and features:

 

first unified presentation of enhanced suffix arrays

up-to-date overview of their applications in computer science and bioinformatics

special emphasis on solving large-scale problems

presentation of space-efficient algorithms on strings, based on the Burrows-Wheeler transform and backward search

comprehensive coverage of sorting by reversals

in-depth study of distance-based phylogenetic reconstruction algorithms

Primarily aimed at graduate or advanced undergraduate students from computer science or bioinformatics, this book will also interest practitioners and researchers from these fields.