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Targeted protein degradation

methods and protocols
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Year: [2021]
Publisher: New York, NY, Humana Press, Springer Science+Business Media, LLC, part of Springer Nature
Series: Methods in molecular biology; 2365
Media group: Dauerleihe
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Branch: Dauerleihe Locations: ME-20 108 Status: borrowed Reservations: 0 Due date: 1/1/2199 Barcode: 00310280 Floor plans: Floor plan Lending note:

Content

This volume contains a collection of innovative techniques for studying targeted protein degradation. Chapters guide readers through heterobifunctional proteolysis-targeting chimeras (PROTACs) approaches, E3 ligase, E3 ligase-induced ubiquitylation, proteomic approaches, novel degrader molecules, molecular glue, and stabilize binding interaction between a target and E3 ubiquitin ligase. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols.
 
Authoritative and cutting-edge, Targeted Protein Degradation: Methods and Protocols aims to ensure successful results in this emerging field of drug discovery.

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Statement of Responsibility: edited by Angela M. Cacace, Christopher M. Hickey, and Miklós Békés, Platform Biology, Arvinas Inc., New Haven CT, USA
Year: [2021]
Publisher: New York, NY, Humana Press, Springer Science+Business Media, LLC, part of Springer Nature
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Classification: Search for this systematic ME-20, ME-30, NA-30
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ISBN: 9781071616642
ISBN (2nd): 1071616641
Description: xi, 351 Seiten, Diagramme, Illustrationen
Series: Methods in molecular biology; 2365
Tags: Pharmakologie; Pharmazie; Proteine
Participating parties: Search for this character Cacace, Angela M. (editor); Hickey, Christopher M. (editor); Békés, Miklós (editor)
Language: Englisch
Media group: Dauerleihe