Bacterial diseases remain a critical issue in public health despite the advent of antibiotics, and the problem presents a rich field for genetic and molecular biology applications. The fourth edition of Virulence Mechanisms of Bacterial Pathogens presents entirely new material on this issue in a ground-breaking overview of the latest knowledge. Internationally recognized authorities explain the wide variety of mechanisms used by bacterial pathogens to cause disease, and then summarize proven strategies for overcoming bacterial virulence mechanisms.
Organized into six accessible sections, this unique volume broadly reviews the pathogenesis of bacterial diseases and mechanisms of host-pathogen interactions for non-specialists and advanced students in the fields of bacteriology and immunology. Beginning with a section on virulence genes, the book continues with sections on pathogenic microbial communities; bacterial attachment, invasion, and colonization; bacterial effects on host cells; and resistance to pathogens. The last section contains a concluding perspective on the state and future of studies on bacterial pathogenicity.
The study of bacterial pathogenicity is now one of the most popular subjects in microbiology. This volume provides an essential source of the latest information on the mechanisms of bacterial pathogens and also serves as a textbook for graduate courses on bacterial pathogenesis. The contents will be vital to specialists in bacterial pathogenicity, such as molecular biologists, physician scientists, dental scientists, veterinarians, molecular biologists, industry researchers, and technicians.
Table of Contents
I. Virulence Genes
Section Editors: F. Chris Minion and Nancy Cornick
1. Type III Secretory Proteins in Pseudomonas aeruginosa, Hiromi Sato and Dara W. Frank
2. Identification and Characterization of Small Noncoding RNAs in Bacterial Pathogens, Jonathan Livny and Matthew Waldor
3. Pathogenesis of Mycobacterium tuberculosis, Michelle H. Larsen, Dee N. Dao, Anthony D. Baughn, Kripa Jalapthy, and William R. Jacobs, Jr.
4. Integration of Capsular Polysaccharide Biosynthesis with Metabolic and Virulence Pathways in Streptococcus pneumoniae, Janet Yother
II. Microbial Interactions in Health and Disease
Section Editor: Thaddeus B. Stanton
5. The Role of Bacteriophage in Group A Streptococcal Pathogenesis, Vincent A. Fischetti
6. Regulatory Networks in Pathogenic Bacteria: Lessons from Cell-Cell Communication in Pseudomonas aeruginosa, Martin Schuster and E. P. Greenberg
7. Coaggregation and Distance-Critical Communication, Paul E. Kolenbrander, Nicholas S. Jakubovics, Natalia I. Chalmers, and Gilad Bachrach
8. Commensal Bacteria in Health and Disease, Harry J. Flint, Petra Louis, Karen P. Scott, and Sylvia H. Duncan
9. Free-Living and Host-Associated Protozoa as Training Camps for Intracellular Pathogens, Steve A. Carlson, Sharon K. Franklin, and Mark A. Rasmussen
III. Bacterial Attachment, Invasion, and Colonization
Section Editor: Qijing Zhang
10. Mycoplasma pneumoniae Attachment and Colonization of the Respiratory Mucosa, Duncan C. Krause, Jarrat L. Jordan, How-Yi Chang, Hyun Kyung Park, and Thomas M. Krunkosky
11. Gender Differences in Neisseria gonorrhoeae Pathogenesis, Jennifer L. Edwards
12. Escherichia coli at the Intestinal Mucosal Surface, Tyrrell Conway and Paul S. Cohen
13. The Role of Flagella in Campylobacter Virulence, Patricia Guerry
IV. Bacterial Effects on Host Cells
Section Editor: Lisa Nolan
14. Role of the Type III Protein Secretion System in Bacterial Infection of Plants, Sheng Yang He
15. Type IV Secretion Systems and Their Role in Eliciting Host Responses to Infection, Christelle M. Roux and Renée M. Tsolis
16. Shiga Toxins (Stxs): Multifaceted Pathogenicity Determinants, Angela R. Melton-Celsa, C. M. Robinson, M. J. Smith, and A. D. O’Brien
V. Innate and Adaptive Resistance to Pathogens
Section Editor: Michael J. Wannemuehler
17. Role of Pattern Recognition Receptors in Modulating Intestinal Immune Responses and Potential Therapeutic Implications for Inflammatory Bowel Diseases, Elke Cario and Daniel K. Podolsky
18. Effect of Defensins on Susceptibility to Infection at the Mucosal Surface, Janet M. Guthmiller and Sophie Joly
19. Antimicrobial Peptides as Mucosal Adjuvants, Lindsey Pingel, Xiaoying Lu, and Kim A. Brogden
20. Induction of Host Immune Responses Using Salmonella-Vectored Vaccines, Roy Curtiss III, Xin Zhang, Soo-Young Wanda, Ho Young Kang, Vjollca Konjufca, Yuhua Li, Bronwyn Gunn, Shifeng Wang, Giorgio Scarpellini, and In Soo Lee
21. Dynamics of the CD8 T-Cell Response Revealed by Listeria monocytogenes Infection, John T. Harty
VI. Concluding Perspective
Section Editor: Kim A. Brogden
22. Studies on Bacterial Pathogenicity since 1950 and Their Future, Harry Smith