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Kurzbeschreibung

Combating the Threat of Pandemic Influenza: Drug Discovery Approaches discusses promising antiviral drug discovery strategies. This publication provides guidance on developing drugs to protect the health of the world against the threat of emerging infectious diseases and bioterrorism.

 

Aus dem Inhalt

1. Existing Influenza Antivirals: The Mechanisms of Action and Potential in the Face of Avial Influenza (Erik De Clercq).

 

2. Development of High-Throughput Screening Assays for Influenza (Diana L. Noah, E. Lucile White, and James W. Noah).

 

3. Mechanisms of IFN Resistance by Influenza Virus (Heather J. Ezelle and Bret A. Hassel).

 

4. Broadly Effective Anti-Respiratory Virus Agents (Shiro Shigeta).

 

5. Current Status on Development of Nucleic Acid-based Antiviral Drugs Against Influenza Virus Inefection (Jonathan P. Wong, Mary E. Christopher, Murray Cairns, L.-Q. Sun, Roderic M.K. Dale, and Andres M. Salazar).

 

6. Antiviral RNAi Strategies Targeting Influenza Virus and Other Respiratory Viruses (Joost Haasnoot and Ben Berkhout).

 

7. Promising Antiviral Glyco-molecules from Edible Algae (Toshimitsu Hayashi, Kyoko Hayashi, Kenji Kanekiyo, Jung-Bum Lee, Takahisa Nakano, and Minoru Hashimoto).

 

8. Rational Design of an Anti-Adhesion Drug for Influenza (Nicolai V. Bovin and Alexandra S. Gambaryan).

 

9. Understanding Influenza Neuraminidase Inhibitors Using Quantitative Structure - Activity Relationship (QSAR) Models (Rajeshwar P. Verma and Corwin Hansch).

 

10. Peptide Inhibitors Targeting Virus-Cell Fusion in Class 1 Enveloped Viruses (George F. Gao).

 

11. Novel Approaches to Influenza Therapeutics (Mang Yu and Lori Aschenbrenner).