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Fc mediated activity of antibodies

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Year: [2019]
Publisher: Cham, Springer Nature Switzerland AG
Series: Current topics in microbiology and immunology; 423
Media group: Serien
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Content

This volume explores several aspects of how antibodies mediate their activity in vivo, ranging from cancer immunotherapy to autoimmunity, infection, and vaccination. Divided into seven chapters, it provides in-depth insights into how antibodies and especially the antibody fragment crystallizable (Fc) domain modulate immune responses and antibody activity. The book begins by discussing evolutionary aspects of how the family of Fc receptors that are the key molecules for antibody activity evolved. In turn, it addresses the molecular and cellular pathways underlying IgG activity in cancer immunotherapy, and focuses on how IgG glycosylation regulates IgG and IgE activity in autoimmunity, allergy and infection. In closing, it presents strategies for developing novel antibody-based vaccination approaches. The book is intended for a very broad readership, including graduate students, postdocs and principal investigators with a basic grasp of immunology.

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Statement of Responsibility: Jeffrey V. Ravetch, Falk Nimmerjahn, editors. Responsible series editor: Rino Rappuoli
Year: [2019]
Publisher: Cham, Springer Nature Switzerland AG
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Classification: Search for this systematic MB-40, ZB-90
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ISBN: 9783030310523
ISBN (2nd): 3030310523
Description: vii, 150 Seiten, Diagramme
Series: Current topics in microbiology and immunology; 423
Tags: Medizinische Mikrobiologie; Immunbiologie
Participating parties: Search for this character Ravetch, Jeffrey V. (editor); Nimmerjahn, Falk (editor); Rappuoli, Rino (editor)
Language: Englisch
Original title: Fc mediated activity of antibodies
Media group: Serien